Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer

QF Han, WJ Li, KS Hu, J Gao, WL Zhai, JH Yang… - Molecular cancer, 2022 - Springer
Exosomes are well-known key mediators of intercellular communication and contribute to
various physiological and pathological processes. Their biogenesis involves four key steps …

A review of the regulatory mechanisms of extracellular vesicles-mediated intercellular communication

YJ Liu, C Wang - Cell Communication and Signaling, 2023 - Springer
Extracellular vesicles (EVs) are small, membrane-bound structures that are released from
cells into the surrounding environment. These structures can be categorized as exosomes …

Exosomes as smart drug delivery vehicles for cancer immunotherapy

H Zhang, S Wang, M Sun, Y Cui, J Xing… - Frontiers in …, 2023 - frontiersin.org
Exosomes (Exos) as drug delivery vehicles have been widely used for cancer
immunotherapy owing to their good biocompatibility, low toxicity, and low immunogenicity …

The distinct roles of exosomes in innate immune responses and therapeutic applications in cancer

J Rezaie, T Etemadi, M Feghhi - European journal of pharmacology, 2022 - Elsevier
The innate immune system is one of the major constituents of the host's defense against
invading pathogens and extracellular vesicles (EVs) are involved in regulating its …

Exosomes: a potential diagnostic and treatment modality in the quest for counteracting cancer

G Patel, TG Agnihotri, M Gitte, T Shinde, SS Gomte… - Cellular Oncology, 2023 - Springer
Background Exosomes are nanosized bio vesicles formed when multivesicular bodies and
the plasma membrane merge and discharge into bodily fluids. They are well recognized for …

Exosomes and exosome-loaded scaffolds: characterization and application in modern regenerative medicine

F Khazaei, L Rezakhani, M Alizadeh, E Mahdavian… - Tissue and Cell, 2023 - Elsevier
Exosomes (EXOs) are extracellular vesicles derived from the endosome. These
heterogeneous nanoparticles (30–150 nm) are secreted from various cells and play …

Engineered exosomes for tumor-targeted drug delivery: a focus on genetic and chemical functionalization

A Akbari, F Nazari-Khanamiri, M Ahmadi, M Shoaran… - Pharmaceutics, 2022 - mdpi.com
Cancer is the main cause of death worldwide. The limitations in traditional cancer therapies
provoked the advance and use of several nanotechnologies for more effective and nontoxic …

Exosomal noncoding RNAs in prostate cancer

A Movahedpour, SH Khatami, N Karami, O Vakili… - Clinica Chimica …, 2022 - Elsevier
Prostate cancer (PCa) is the second most common cancer and the fifth leading cause of
mortality among men. The recurrent reports of false-positive results of common PCa …

Therapeutic application of mesenchymal stem cells derived exosomes in neurodegenerative diseases: a focus on non-coding RNAs cargo, drug delivery potential …

M Hedayat, M Ahmadi, M Shoaran, J Rezaie - Life Sciences, 2023 - Elsevier
Despite the massive efforts advanced over recent years in emerging therapies for
neurodegenerative diseases, effective treatment for these diseases is still an urgent need …

Harnessing normal and engineered mesenchymal stem cells derived exosomes for cancer therapy: opportunity and challenges

M Ahmadi, M Mahmoodi, M Shoaran… - International Journal of …, 2022 - mdpi.com
There remains a vital necessity for new therapeutic approaches to combat metastatic
cancers, which cause globally over 8 million deaths per year. Mesenchymal stem cells …