Highlights (AQPs) are transmembrane proteins responsible for fast water movement across
cell membranes, including those of astrocytes. The expression and subcellular localization …

Abstract Aims Reactive astrocytes in Alzheimer's disease (AD) have traditionally been
demonstrated by increased glial fibrillary acidic protein (GFAP) immunoreactivity; however …

Stress granules (SGs) are cytoplasmic foci that form in response to various external stimuli
and are essential to cell survival following stress. SGs are studied in several diseases …

Since the discovery of aquaporins, it has become clear that the various mammalian
aquaporins play critical physiological roles in water and ion balance in multiple tissues …

Astrogliopathy refers to alterations of astrocytes occurring in diseases of the nervous system,
and it implies the involvement of astrocytes as key elements in the pathogenesis and …

Three aquaporins are expressed in the brain. AQP4, the predominant brain water channel,
is expressed in astrocyte endfeet facing brain capillaries, perisynaptic spaces, and nodes of …

Astrocytes perform control and regulatory functions in the central nervous system;
heterogeneity among them is still a matter of debate due to limited knowledge of their gene …

The impairment of amyloid-β (Aβ) clearance in the brain plays a causative role in
Alzheimer's disease (AD). Polarity distribution of aquaporin-4 (AQP4) is important to remove …

Regular exercise has been shown to reduce the risk of Alzheimer's disease (AD). Our
previous study showed that the protein aquaporin 4 (AQP4), which is specifically expressed …

Senile plaques (SPs) containing amyloid β peptide (Aβ) 1–42 are the major species present
in Alzheimer disease (AD), whereas Aβ1–40 is the major constituent of arteriolar walls …