The pro-inflammatory immune response driven by microglia is a key contributor to the
pathogenesis of several neurodegenerative diseases. Though the research of microglia …

Neuroinflammation is an inflammatory response in the brain and spinal cord, which can
involve the activation of microglia and astrocytes. It is a common feature of many central …

Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer's
disease (AD), suggesting that activation of this innate immune receptor may be a useful …

2-Deoxy-2-[18F] fluoro-d-glucose positron emission tomography (FDG-PET) is widely used
to study cerebral glucose metabolism. Here, we investigated whether the FDG-PET signal is …

Coding variants in the triggering receptor expressed on myeloid cells 2 (TREM2) are
associated with late-onset Alzheimer's disease (AD). We demonstrate that amyloid plaque …

Microglia activation is the brain's major immune response to amyloid plaques in Alzheimer's
disease (AD). Both cerebrospinal fluid (CSF) levels of soluble TREM2 (sTREM2), a …

Haploinsufficiency of the progranulin (PGRN)‐encoding gene (GRN) causes frontotemporal
lobar degeneration (GRN‐FTLD) and results in microglial hyperactivation, TREM2 …

Benzodiazepines are widely administered drugs to treat anxiety and insomnia. In addition to
tolerance development and abuse liability, their chronic use may cause cognitive …

Genetic variants in the triggering receptor expressed on myeloid cells 2 (TREM 2) increase
the risk for several neurodegenerative diseases including Alzheimer's disease and …

The high energetic demand of the brain deems this organ rather sensitive to changes in
energy supply. Therefore, even minor alterations in energy metabolism may underlie …