RNA dependent RNA polymerases: insights from structure, function and evolution
RNA dependent RNA polymerase (RdRp) is one of the most versatile enzymes of RNA
viruses that is indispensable for replicating the genome as well as for carrying out …
viruses that is indispensable for replicating the genome as well as for carrying out …
Nucleoside, nucleotide, and non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA-polymerase
Hepatitis C virus (HCV) infection is a global health problem that impacts approximately 180
million individuals. Of those initially infected with HCV approximately 80% will progress to …
million individuals. Of those initially infected with HCV approximately 80% will progress to …
Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms
LJ Stevens, AJ Pruijssers, HW Lee… - Science translational …, 2022 - science.org
The nucleoside analog remdesivir (RDV) is a Food and Drug Administration–approved
antiviral for treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
antiviral for treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency
CJ Gordon, EP Tchesnokov, E Woolner… - Journal of Biological …, 2020 - ASBMB
Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed to control
this current pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS …
this current pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS …
Structure of influenza A polymerase bound to the viral RNA promoter
A Pflug, D Guilligay, S Reich, S Cusack - Nature, 2014 - nature.com
The influenza virus polymerase transcribes or replicates the segmented RNA genome (viral
RNA) into viral messenger RNA or full-length copies. To initiate RNA synthesis, the …
RNA) into viral messenger RNA or full-length copies. To initiate RNA synthesis, the …
[HTML][HTML] Structural basis for substrate selection by the SARS-CoV-2 replicase
Abstract The SARS-CoV-2 RNA-dependent RNA polymerase coordinates viral RNA
synthesis as part of an assembly known as the replication–transcription complex (RTC) …
synthesis as part of an assembly known as the replication–transcription complex (RTC) …
Structural basis for RNA replication by the hepatitis C virus polymerase
TC Appleby, JK Perry, E Murakami, O Barauskas… - Science, 2015 - science.org
Nucleotide analog inhibitors have shown clinical success in the treatment of hepatitis C virus
(HCV) infection, despite an incomplete mechanistic understanding of NS5B, the viral RNA …
(HCV) infection, despite an incomplete mechanistic understanding of NS5B, the viral RNA …
Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral
L Delang, N Segura Guerrero, A Tas… - Journal of …, 2014 - academic.oup.com
Objectives T-705, also known as favipiravir, is a small-molecule inhibitor that is currently in
clinical development for the treatment of influenza virus infections. This molecule also …
clinical development for the treatment of influenza virus infections. This molecule also …
Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase
P Gong, OB Peersen - … of the National Academy of Sciences, 2010 - National Acad Sciences
Positive-strand RNA viruses include a large number of human and animal pathogens whose
essential RNA-dependent RNA polymerases (RdRPs) share a structurally homologous core …
essential RNA-dependent RNA polymerases (RdRPs) share a structurally homologous core …
A structure-function diversity survey of the RNA-dependent RNA polymerases from the positive-strand RNA viruses
H Jia, P Gong - Frontiers in Microbiology, 2019 - frontiersin.org
The RNA-dependent RNA polymerases (RdRPs) encoded by the RNA viruses are a unique
class of nucleic acid polymerases. Each viral RdRP contains a 500–600 residue catalytic …
class of nucleic acid polymerases. Each viral RdRP contains a 500–600 residue catalytic …