The prevalence of heart failure is on the rise and imposes a major health threat, in part, due
to the rapidly increased prevalence of overweight and obesity. To this point …

The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …

Meteorin-like (METRNL) protein is a newly identified myokine that functions to modulate
energy expenditure and inflammation in adipose tissue. Herein, we aim to investigate the …

Obesity mediates most of its direct medical sequelae through the development of insulin
resistance (IR). The cellular effects of insulin occur through two main postreceptor pathways …

As a master regulator of metabolism, AMP-activated protein kinase (AMPK) is activated upon
energy and glucose shortage but suppressed upon overnutrition. Exaggerated negative …

Background: Cardiac ischemia/reperfusion (I/R) injury has emerged as an important
therapeutic target for ischemic heart disease, the leading cause of morbidity and mortality …

Insulin receptors are highly expressed in the heart and vasculature. Insulin signaling
regulates cardiac growth, survival, substrate uptake, utilization, and mitochondrial …

Due to the essential role of cyclin D1 in regulating transition from G1 to S phase in cell cycle,
aberrant cyclin D1 expression is a major oncogenic event in many types of cancers. In …

A highly complex network of organ communication plays a key role in regulating metabolic
homeostasis, specifically due to the modulation of the insulin signaling machinery. As a …

Ras-related C3 botulinum toxin substrate 1 (RAC1) overexpressiosn and hyperactivation are
correlated with aggressive growth and other malignant characteristics in a wide variety of …