[HTML][HTML] The evolving landscape of biomarker testing for non-small cell lung cancer in Europe
KM Kerr, F Bibeau, E Thunnissen, J Botling, A Ryška… - Lung Cancer, 2021 - Elsevier
The discovery of oncogenic driver mutations rendering non-small cell lung cancer (NSCLC)
targetable by small-molecule inhibitors, and the development of immunotherapies, have …
targetable by small-molecule inhibitors, and the development of immunotherapies, have …
[HTML][HTML] Pathological features and prognostication in colorectal cancer
The prognostication of colorectal cancer (CRC) has traditionally relied on staging as defined
by the Union for International Cancer Control (UICC) and American Joint Committee on …
by the Union for International Cancer Control (UICC) and American Joint Committee on …
Adenomyosis pathogenesis: insights from next-generation sequencing
BACKGROUND Adenomyosis, characterized by the presence of islands of endometrial
tissue surrounded by hypertrophic smooth muscle cells within the myometrium, is one of the …
tissue surrounded by hypertrophic smooth muscle cells within the myometrium, is one of the …
[HTML][HTML] The current understanding on the impact of KRAS on colorectal cancer
M Meng, K Zhong, T Jiang, Z Liu, HY Kwan… - Biomedicine & …, 2021 - Elsevier
KRAS (kirsten rat sarcoma viral oncogene) is a member of the RAS family. KRAS mutations
are one of most dominant mutations in colorectal cancer (CRC). The impact of KRAS …
are one of most dominant mutations in colorectal cancer (CRC). The impact of KRAS …
[HTML][HTML] Novel insights on the use of L-asparaginase as an efficient and safe anti-cancer therapy
M Van Trimpont, E Peeters, Y De Visser, AM Schalk… - Cancers, 2022 - mdpi.com
Simple Summary L-asparaginase (L-ASNase) therapy is key for achieving the very high cure
rate of pediatric acute lymphoblastic leukemia (ALL), yet its use is mostly confined to this …
rate of pediatric acute lymphoblastic leukemia (ALL), yet its use is mostly confined to this …
Precision medicine: Ray of hope in overcoming cancer multidrug resistance
P Musyuni, J Bai, A Sheikh, KS Vasanthan… - Drug Resistance …, 2022 - Elsevier
Multi-drug resistance (MDR) developed in response to chemotherapy is one of the
prominent causes of therapeutic failure. The major underlying factors that contribute to such …
prominent causes of therapeutic failure. The major underlying factors that contribute to such …
Role and mechanism of autophagy‐regulating factors in tumorigenesis and drug resistance
RM Usman, F Razzaq, A Akbar… - Asia‐Pacific Journal …, 2021 - Wiley Online Library
A hallmark feature of tumorigenesis is uncontrolled cell division. Autophagy is regulated by
more than 30 genes and it is one of several mechanisms by which cells maintain …
more than 30 genes and it is one of several mechanisms by which cells maintain …
[HTML][HTML] Progress on Ras/MAPK signaling research and targeting in blood and solid cancers
M Dillon, A Lopez, E Lin, D Sales, R Perets, P Jain - Cancers, 2021 - mdpi.com
Simple Summary The Ras-Raf-MEK-ERK signaling pathway is responsible for regulating
cell proliferation, differentiation, and survival. Overexpression and overactivation of …
cell proliferation, differentiation, and survival. Overexpression and overactivation of …
Mutant ATRX: uncovering a new therapeutic target for glioma
S Haase, MB Garcia-Fabiani, S Carney… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: ATRX is a chromatin remodeling protein whose main function is the deposition
of the histone variant H3. 3. ATRX mutations are widely distributed in glioma, and correlate …
of the histone variant H3. 3. ATRX mutations are widely distributed in glioma, and correlate …
[HTML][HTML] Tumor microenvironment shapes colorectal cancer progression, metastasis, and treatment responses
J Li, D Chen, M Shen - Frontiers in medicine, 2022 - frontiersin.org
Colorectal cancer (CRC) is one of the most devastating diseases that accounts for numerous
deaths worldwide. Tumor cell-autonomous pathways, such as the oncogenic signaling …
deaths worldwide. Tumor cell-autonomous pathways, such as the oncogenic signaling …