The discovery of oncogenic driver mutations rendering non-small cell lung cancer (NSCLC)
targetable by small-molecule inhibitors, and the development of immunotherapies, have …

The prognostication of colorectal cancer (CRC) has traditionally relied on staging as defined
by the Union for International Cancer Control (UICC) and American Joint Committee on …

BACKGROUND Adenomyosis, characterized by the presence of islands of endometrial
tissue surrounded by hypertrophic smooth muscle cells within the myometrium, is one of the …

KRAS (kirsten rat sarcoma viral oncogene) is a member of the RAS family. KRAS mutations
are one of most dominant mutations in colorectal cancer (CRC). The impact of KRAS …

Simple Summary L-asparaginase (L-ASNase) therapy is key for achieving the very high cure
rate of pediatric acute lymphoblastic leukemia (ALL), yet its use is mostly confined to this …

Multi-drug resistance (MDR) developed in response to chemotherapy is one of the
prominent causes of therapeutic failure. The major underlying factors that contribute to such …

A hallmark feature of tumorigenesis is uncontrolled cell division. Autophagy is regulated by
more than 30 genes and it is one of several mechanisms by which cells maintain …

Simple Summary The Ras-Raf-MEK-ERK signaling pathway is responsible for regulating
cell proliferation, differentiation, and survival. Overexpression and overactivation of …

Introduction: ATRX is a chromatin remodeling protein whose main function is the deposition
of the histone variant H3. 3. ATRX mutations are widely distributed in glioma, and correlate …

Colorectal cancer (CRC) is one of the most devastating diseases that accounts for numerous
deaths worldwide. Tumor cell-autonomous pathways, such as the oncogenic signaling …