Noncoding RNAs as regulators of STAT3 pathway in gastrointestinal cancers: Roles in cancer progression and therapeutic response

M Ashrafizadeh, CD Mohan… - Medicinal research …, 2023 - Wiley Online Library
Gastrointestinal (GI) tumors (cancers of the esophagus, gastric, liver, pancreas, colon, and
rectum) contribute to a large number of deaths worldwide. STAT3 is an oncogenic …

Ketogenic diet in cancer prevention and therapy: molecular targets and therapeutic opportunities

WH Talib, AI Mahmod, A Kamal, HM Rashid… - Current issues in …, 2021 - mdpi.com
Although cancer is still one of the most significant global challenges facing public health, the
world still lacks complementary approaches that would significantly enhance the efficacy of …

Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer

F Lin, X Li, X Wang, H Sun, Z Wang, X Wang - Journal of Experimental & …, 2022 - Springer
Abstract Background Stanniocalcin 1 (STC1) plays an integral role in ovarian cancer (OC).
However, the functional role of STC1 in metastasis, lipid metabolism and cisplatin (DDP) …

Current options and future directions for NAFLD and NASH treatment

C Zhang, M Yang - International Journal of Molecular Sciences, 2021 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide, with a broad spectrum ranging from simple steatosis to advanced stage of …

Pathology and pathogenesis of metabolic dysfunction-associated steatotic liver disease-associated hepatic tumors

Y Takahashi, E Dungubat, H Kusano, T Fukusato - Biomedicines, 2023 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive fat accumulation in
the livers of patients without a history of alcohol abuse. It is classified as either simple …

Diagnosis and therapeutic management of liver fibrosis by MicroRNA

T Tadokoro, A Morishita, T Masaki - International Journal of Molecular …, 2021 - mdpi.com
Remarkable progress has been made in the treatment and control of hepatitis B and C viral
infections. However, fundamental treatments for diseases in which liver fibrosis is a key …

[HTML][HTML] MicroRNAs in the pathogenesis of nonalcoholic fatty liver disease

Z Fang, G Dou, L Wang - International journal of biological …, 2021 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD), or, more accurately, metabolic associated fatty
liver disease, accounts for a large proportion of chronic liver disorders worldwide and is …

miR‐21‐5p promotes NASH‐related hepatocarcinogenesis

PM Rodrigues, MB Afonso, AL Simão, T Islam… - Liver …, 2023 - Wiley Online Library
Abstract Background and Aims The mechanisms governing the progression of non‐
alcoholic fatty liver disease (NAFLD) towards steatohepatitis (NASH) and hepatocellular …

[HTML][HTML] Glycyrrhetinic acid regulates impaired macrophage autophagic flux in the treatment of non-alcoholic fatty liver disease

Y Fan, W Dong, Y Wang, S Zhu, R Chai, Z Xu… - Frontiers in …, 2022 - frontiersin.org
Macrophages are involved in hepatocyte steatosis and necroinflammation and play an
important role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Impaired …

Zebrafish facilitate non‐alcoholic fatty liver disease research: Tools, models and applications

C Chang, H Li, R Zhang - Liver International, 2023 - Wiley Online Library
Non‐alcoholic fatty liver disease (NAFLD) has become an increasingly epidemic metabolic
disease worldwide. NAFLD can gradually deteriorate from simple liver steatosis …