• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

The focus of the “2014 AHA/ACC Guideline for the Management of Patients With Valvular
Heart Disease” 9, 10 (2014 VHD guideline) was the diagnosis and management of adult …

The recommendations listed in this document are, whenever possible, evidence based. An
extensive review was conducted on literature published through March 1, 2020. Searches …

Aim This executive summary of the valvular heart disease guideline provides
recommendations for clinicians to diagnose and manage valvular heart disease as well as …

Background—Infective endocarditis is a potentially lethal disease that has undergone major
changes in both host and pathogen. The epidemiology of infective endocarditis has become …

LRRC4 is a novel relatively specific gene, which displays significant down-regulation in
primary brain tumor biopsies and has the potential to suppress brain tumor growth. In this …

Importance Infective endocarditis occurs in approximately 15 of 100 000 people in the
United States and has increased in incidence. Clinicians must make treatment decisions …

The recommendations listed in this document are, whenever possible, evidence based. An
extensive review was conducted on literature published through November 2012, and other …

Guidelines (Task Force) directs this effort by developing, updating, and revising practice
guidelines for cardiovascular diseases and procedures. Experts in the subject under …

Potential Biases Most studies of IE are affected by selection, survival, and referral bias. They
make it difficult to study the natural history of IE in the general population, because treated …