A long-term complication of obesity is the development of type 2 diabetes (T2D). Patients
with T2D have been described as having epigenetic modifications. Epigenetics is the post …

Proopiomelanocortin (POMC) is a key mediator of satiety. Epigenetic marks such as DNA
methylation may modulate POMC expression and provide a biological link between early life …

Childhood trauma (CT) is well established as a potent risk factor for the development of
mental disorders. However, the potential of adverse early experiences to exert chronic and …

Hepatocyte nuclear factor 4-alpha (HNF4α) is a highly conserved member of nuclear
receptor superfamily of ligand-dependent transcription factors that is expressed in liver and …

The epidemic of obesity has become pandemic, putting a significant burden on the world's
healthcare system. While the heritability of the disease is high, all the identified genetic …

The molecular mechanism of liver fibrosis caused by hepatitis C virus (HCV) is not clear. The
aim of this study is to understand the molecular mechanism of liver fibrosis induced by HCV …

Prenatal exposure to bisphenol A (BPA) may increase the risk of abnormal birth outcomes,
and DNA methylation might mediate these adverse effects. This study aimed to investigate …

Background Obesity is a major worldwide threat to human health. Increasing evidence
indicates that epigenetic modifications have a major impact on the natural history of this …

Background Maternal metabolic insults as well as Gestational Diabetes Mellitus (GDM)
influence the fetal health and may affect 'offspring's susceptibility to chronic diseases via …

Lipids are a major source of energy during the fetal/neonatal period. Most are received from
the mother, either transplacentally during the intrauterine period or via maternal milk after …