Epigenetics in obesity and diabetes mellitus: new insights
R Suárez, SP Chapela, L Álvarez-Córdova… - Nutrients, 2023 - mdpi.com
A long-term complication of obesity is the development of type 2 diabetes (T2D). Patients
with T2D have been described as having epigenetic modifications. Epigenetics is the post …
with T2D have been described as having epigenetic modifications. Epigenetics is the post …
[HTML][HTML] Epigenetic regulation of POMC; implications for nutritional programming, obesity and metabolic disease
T Candler, P Kühnen, AM Prentice, M Silver - Frontiers in …, 2019 - Elsevier
Proopiomelanocortin (POMC) is a key mediator of satiety. Epigenetic marks such as DNA
methylation may modulate POMC expression and provide a biological link between early life …
methylation may modulate POMC expression and provide a biological link between early life …
Childhood trauma, the stress response and metabolic syndrome: a focus on DNA methylation
Childhood trauma (CT) is well established as a potent risk factor for the development of
mental disorders. However, the potential of adverse early experiences to exert chronic and …
mental disorders. However, the potential of adverse early experiences to exert chronic and …
[HTML][HTML] Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases
MM Yeh, DE Bosch, SS Daoud - World journal of gastroenterology, 2019 - ncbi.nlm.nih.gov
Hepatocyte nuclear factor 4-alpha (HNF4α) is a highly conserved member of nuclear
receptor superfamily of ligand-dependent transcription factors that is expressed in liver and …
receptor superfamily of ligand-dependent transcription factors that is expressed in liver and …
The role of epigenetics in the development of obesity
A Obri, D Serra, L Herrero, P Mera - Biochemical Pharmacology, 2020 - Elsevier
The epidemic of obesity has become pandemic, putting a significant burden on the world's
healthcare system. While the heritability of the disease is high, all the identified genetic …
healthcare system. While the heritability of the disease is high, all the identified genetic …
Identification of TAF1, HNF4A, and CALM2 as potential therapeutic target genes for liver fibrosis
D Ji, GF Chen, JC Wang, LH Cao, F Lu… - Journal of Cellular …, 2019 - Wiley Online Library
The molecular mechanism of liver fibrosis caused by hepatitis C virus (HCV) is not clear. The
aim of this study is to understand the molecular mechanism of liver fibrosis induced by HCV …
aim of this study is to understand the molecular mechanism of liver fibrosis induced by HCV …
Prenatal bisphenol A exposure, DNA methylation, and low birth weight: a pilot study in Taiwan
Prenatal exposure to bisphenol A (BPA) may increase the risk of abnormal birth outcomes,
and DNA methylation might mediate these adverse effects. This study aimed to investigate …
and DNA methylation might mediate these adverse effects. This study aimed to investigate …
Epigenetic silencing of the ANKRD26 gene correlates to the pro-inflammatory profile and increased cardio-metabolic risk factors in human obesity
Background Obesity is a major worldwide threat to human health. Increasing evidence
indicates that epigenetic modifications have a major impact on the natural history of this …
indicates that epigenetic modifications have a major impact on the natural history of this …
The obesogenic environment: Epigenetic modifications in placental melanocortin 4 receptor gene connected to gestational diabetes and smoking
M Franzago, A Porreca, M D'Ardes, M Di Nicola… - Frontiers in …, 2022 - frontiersin.org
Background Maternal metabolic insults as well as Gestational Diabetes Mellitus (GDM)
influence the fetal health and may affect 'offspring's susceptibility to chronic diseases via …
influence the fetal health and may affect 'offspring's susceptibility to chronic diseases via …
[PDF][PDF] Human milk lipids induce important metabolic and epigenetic changes in Neonates
K Donda, A Maheshwari - Clinics in perinatology, 2022 - Elsevier
Lipids are a major source of energy during the fetal/neonatal period. Most are received from
the mother, either transplacentally during the intrauterine period or via maternal milk after …
the mother, either transplacentally during the intrauterine period or via maternal milk after …