Mechanisms of inflammatory responses and development of insulin resistance: how are they interlinked?

K Rehman, MSH Akash - Journal of biomedical science, 2016 - Springer
Background Insulin resistance (IR) is one of the major hallmark for pathogenesis and
etiology of type 2 diabetes mellitus (T2DM). IR is directly interlinked with various …

Mucosal applications of poloxamer 407-based hydrogels: An overview

E Giuliano, D Paolino, M Fresta, D Cosco - Pharmaceutics, 2018 - mdpi.com
Poloxamer 407, also known by the trademark Pluronic® F127, is a water-soluble, non-ionic
triblock copolymer that is made up of a hydrophobic residue of polyoxypropylene (POP) …

Recent progress in biomedical applications of Pluronic (PF127): Pharmaceutical perspectives

MSH Akash, K Rehman - Journal of Controlled Release, 2015 - Elsevier
Most of the administered anti-cancer drugs are hydrophobic in nature and are known to
have poor water solubility, short residence time, rapid clearance from the body and systemic …

Smart polymeric hydrogels for cartilage tissue engineering: a review on the chemistry and biological functions

N Eslahi, M Abdorahim, A Simchi - Biomacromolecules, 2016 - ACS Publications
Stimuli responsive hydrogels (SRHs) are attractive bioscaffolds for tissue engineering. The
structural similarity of SRHs to the extracellular matrix (ECM) of many tissues offers great …

Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus

MSH Akash, K Rehman, S Chen - Journal of cellular …, 2013 - Wiley Online Library
Type 2 diabetes mellitus (T2DM) is characterized by progressive β‐cell dysfunctioning and
insulin resistance. This article reviews recent literature with special focus on inflammatory …

Thermoresponsive hydrogels and their biomedical applications: Special insight into their applications in textile based transdermal therapy

S Chatterjee, PC Hui, C Kan - Polymers, 2018 - mdpi.com
Various natural and synthetic polymers are capable of showing thermoresponsive properties
and their hydrogels are finding a wide range of biomedical applications including drug …

Recent developments in protein and peptide parenteral delivery approaches

A Patel, K Cholkar, AK Mitra - Therapeutic delivery, 2014 - Taylor & Francis
Discovery of insulin in the early 1900s initiated the research and development to improve
the means of therapeutic protein delivery in patients. In the past decade, great emphasis has …

Effects of coffee on type 2 diabetes mellitus

MSH Akash, K Rehman, S Chen - Nutrition, 2014 - Elsevier
This review provides the epidemiologic and research evidences documenting the effects of
coffee consumption on type 2 diabetes mellitus (T2DM). We summarize the literature …

Natural and synthetic polymers as drug carriers for delivery of therapeutic proteins

MS Hamid Akash, K Rehman, S Chen - Polymer Reviews, 2015 - Taylor & Francis
In order to cure and treat health-related disorders, therapeutic substance must reach its
target site with a constant concentration over a long period of time. As oral administration is …

GSK3 inhibitor-loaded osteotropic Pluronic hydrogel effectively mitigates periodontal tissue damage associated with experimental periodontitis

Y Almoshari, R Ren, H Zhang, Z Jia, X Wei, N Chen… - Biomaterials, 2020 - Elsevier
Periodontitis is a chronic inflammatory disease caused by complex interactions between the
host immune system and pathogens that affect the integrity of periodontium. To prevent …