The central component in the road trip of axon guidance is the growth cone, a dynamic
structure that is located at the tip of the growing axon. During its journey, the growth cone …

Growth cones, found at the tip of axonal projections, are the sensory and motile organelles
of developing neurons that enable axon pathfinding and target recognition for precise wiring …

The formation of axons and dendrites and maintenance of the neuron's vastly expanded
surface require the continuous addition of new membrane. This is achieved by membrane …

Central nerve terminals release neurotransmitter in response to a wide variety of stimuli.
Because maintenance of neurotransmitter release is dependent on the continual supply of …

Once thought of primarily as a means to neutralize pathogens or to facilitate feeding,
endocytosis is now known to regulate a wide range of eukaryotic cell processes. Among …

Endocytosis and endosomal trafficking play a multitude of roles in cellular function beyond
regulating entry of essential nutrients. In this review, we discuss the cell biological principles …

Dynamin-1 (Dnm1) encodes a large multimeric GTPase necessary for activity-dependent
membrane recycling in neurons, including synaptic vesicle endocytosis. Mice heterozygous …

Macropinocytosis is a widely-observed and evolutionarily-conserved endocytic process
found in the eukaryotic cells. In comparison to other endocytic routes, macropinocytosis …

With the onset of the rapidly aging population, the impact of age related neurodegenerative
diseases is becoming a predominant health and economic concern. Neurodegenerative …

Neuron navigators (Navigators) are cytoskeletal-associated proteins important for neuron
migration, neurite growth, and axon guidance, but they also function more widely in other …