Epigenome-wide association studies (EWAS) hold promise for the detection of new
regulatory mechanisms that may be susceptible to modification by environmental and …

It is now well-established that somatic cells can be reprogrammed to alternative cell fates by
ectopic coexpression of defined factors. Reprogramming technology has uncovered a huge …

A major fraction of the transcriptome of higher organisms comprised an extensive repertoire
of long non-coding RNA (lncRNA) which express in a cell type and development stage …

Abstract Background Pigs (Sus scrofa) provide relevant biomedical models to dissect
complex diseases due to their anatomical, genetic, and physiological similarities with …

Genomic imprinting is an epigenetic phenomenon resulting in parent-of-origin-specific gene
expression that is regulated by a differentially methylated region. Gene mutations or failures …

Studies designed to identify novel methylation events related to cancer often employ cancer
cell lines in the discovery phase of the experiments and have a relatively low rate of …

Phenotypic variation results from variation in gene expression, which is modulated by
genetic and/or epigenetic factors. To understand the molecular basis of human disease …

The FK506 binding protein 51 (FKBP5), an intrinsic regulator of the glucocorticoid receptor,
has been associated with pathological behaviors particularly in the context of childhood …

Background Patient-derived tumour xenografts are an attractive model for preclinical testing
of anti-cancer drugs. Insights into tumour biology and biomarkers predictive of responses to …

Background Two asthma-associated regions 17q12–q21 and 5q31. 1 harbour genes that
show strong effect of genotype on expression levels. DNA methylation has an important role …