An evolving new paradigm: endothelial cells–conditional innate immune cells

J Mai, A Virtue, J Shen, H Wang, XF Yang - Journal of hematology & …, 2013 - Springer
Endothelial cells (ECs) are a heterogeneous population that fulfills many physiological
processes. ECs also actively participate in both innate and adaptive immune responses …

Chemokines in cutaneous wound healing

R Gillitzer, M Goebeler - Journal of leukocyte biology, 2001 - academic.oup.com
Healing of wounds is one of the most complex biological events afterbirth as a result of the
interplay of different tissue structures and alarge number of resident and infiltrating cell …

IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis

A Li, S Dubey, ML Varney, BJ Dave… - The Journal of …, 2003 - journals.aai.org
IL-8, a member of the chemokine family, has been shown to play an important role in tumor
growth, angiogenesis, and metastasis. The objective of this study was to determine the …

The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis

DJ Brat, AC Bellail, EG Van Meir - Neuro-oncology, 2005 - academic.oup.com
Abstract Interleukin-8 (IL-8, or CXCL8), which is a chemokine with a defining CXC amino
acid motif that was initially characterized for its leukocyte chemotactic activity, is now known …

Chemokines in health and disease

D Raman, T Sobolik-Delmaire, A Richmond - Experimental cell research, 2011 - Elsevier
Chemokines and their receptors play a key role in development and homeostasis as well as
in the pathogenesis of tumors and autoimmune diseases. Chemokines are involved in the …

Chemokine receptors and their role in inflammation and infectious diseases

C Murdoch, A Finn - Blood, The Journal of the American Society …, 2000 - ashpublications.org
Chemokines are small peptides that are potent activators and chemoattractants for leukocyte
subpopulations and some nonhemopoietic cells. Their actions are mediated by a family of 7 …

[HTML][HTML] Large and sustained induction of chemokines during impaired wound healing in the genetically diabetic mouse: prolonged persistence of neutrophils and …

C Wetzler, H Kämpfer, B Stallmeyer… - Journal of investigative …, 2000 - Elsevier
Chemokines are seen as the stimuli that largely control leukocyte migration. To assess
whether the severely impaired process of cutaneous repair observed in genetically diabetic …

[HTML][HTML] Lipopolysaccharide signaling in endothelial cells

SM Dauphinee, A Karsan - Laboratory investigation, 2006 - Elsevier
Sepsis is the systemic immune response to severe bacterial infection. The innate immune
recognition of bacterial and viral products is mediated by a family of transmembrane …

Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development

SJ Huh, S Liang, A Sharma, C Dong, GP Robertson - Cancer research, 2010 - AACR
It is unknown why only a minority of circulating tumor cells trapped in lung capillaries form
metastases and involvement of immune cells remains uncertain. A novel model has been …

The potential role of neutrophils in promoting the metastatic phenotype of tumors releasing interleukin-8

JE De Larco, BRK Wuertz, LT Furcht - Clinical Cancer Research, 2004 - AACR
In the last decade, several groups have shown a direct correlation between the
inappropriate or ectopic release of interleukin (IL)-8 by tumor cells in vitro and their growth …