Suicide and suicide risk

G Turecki, DA Brent, D Gunnell, RC O'Connor… - Nature reviews Disease …, 2019 - nature.com
Although recent years have seen large decreases in the overall global rate of suicide
fatalities, this trend is not reflected everywhere. Suicide and suicidal behaviour continue to …

[HTML][HTML] A brain-centric model of suicidal behavior

JJ Mann, MM Rizk - American journal of psychiatry, 2020 - Am Psychiatric Assoc
The suicide death toll is alarmingly high, outnumbering deaths from war and homicide
worldwide (1). Many factors contribute to suicide death, making it difficult to prevent because …

Genome-wide association study meta-analysis of suicide death and suicidal behavior

QS Li, AA Shabalin, E DiBlasi, S Gopal… - Molecular …, 2023 - nature.com
Suicide is a worldwide health crisis. We aimed to identify genetic risk variants associated
with suicide death and suicidal behavior. Meta-analysis for suicide death was performed …

Identification of novel genome-wide associations for suicidality in UK Biobank, genetic correlation with psychiatric disorders and polygenic association with completed …

RJ Strawbridge, J Ward, A Ferguson, N Graham… - …, 2019 - thelancet.com
Background Suicide is a major issue for global public health. Suicidality describes a broad
spectrum of thoughts and behaviours, some of which are common in the general population …

Genetics and brain transcriptomics of completed suicide

G Punzi, G Ursini, Q Chen… - American journal of …, 2022 - Am Psychiatric Assoc
Objective: The authors sought to study the transcriptomic and genomic features of completed
suicide by parsing the method chosen, to capture molecular correlates of the distinctive …

Identification of potential blood biomarkers associated with suicide in major depressive disorder

F Mamdani, MD Weber, B Bunney, K Burke… - Translational …, 2022 - nature.com
Suicides have increased to over 48,000 deaths yearly in the United States. Major depressive
disorder (MDD) is the most common diagnosis among suicides, and identifying those at the …

Suicide risk assessment and prevention: challenges and opportunities

EP Ryan, MA Oquendo - Focus, 2020 - Am Psychiatric Assoc
Despite increased access to mental health care for the previously uninsured and expanding
evidence-based treatments for mood, anxiety, psychotic, and substance use disorders …

Genome-wide association study of suicide death and polygenic prediction of clinical antecedents

AR Docherty, AA Shabalin, E DiBlasi… - American journal of …, 2020 - Am Psychiatric Assoc
Objective: Death by suicide is a highly preventable yet growing worldwide health crisis. To
date, there has been a lack of adequately powered genomic studies of suicide, with no …

Identification of transcriptome alterations in the prefrontal cortex, hippocampus, amygdala and hippocampus of suicide victims

D Glavan, V Gheorman, A Gresita, DM Hermann… - Scientific Reports, 2021 - nature.com
Suicide is one of the leading causes of death globally for all ages, and as such presents a
very serious problem for clinicians worldwide. However, the underlying neurobiological …

Genetics and epigenetics of self‐injurious thoughts and behaviors: Systematic review of the suicide literature and methodological considerations

S Mirza, AR Docherty, A Bakian, H Coon… - American Journal of …, 2022 - Wiley Online Library
Suicide is a multifaceted and poorly understood clinical outcome, and there is an urgent
need to advance research on its phenomenology and etiology. Epidemiological studies …