Regulated cell death is a vital and dynamic process in multicellular organisms that maintains
tissue homeostasis and eliminates potentially dangerous cells. Apoptosis, one of the better …

Neurotrophins were christened in consideration of their actions on the nervous system and,
for a long time, they were the exclusive interest of neuroscientists. However, more recently …

The neurotrophins, a class of four related growth factors, utilize a dual receptor system
consisting of Trk receptor tyrosine kinases and the structurally unrelated p75 NTR to …

TRADD (TNFR1-associated death domain protein) was initially identified as an adaptor
molecule that transduces the signal downstream of the TNFR1 (tumor necrosis factor …

Recent studies have identified novel subgroups in ER-negative breast cancer based on the
expression pattern of androgen receptor (AR). One subtype (molecular apocrine) has an …

Nerve growth factor (NGF) and its precursor (proNGF) are primarily considered as regulators
of neuronal function that induce their responses via the tyrosine kinase receptor TrkA and …

Death receptors are members of the tumour necrosis factor (TNF) receptor superfamily
characterised by an~ 80 amino acid long alpha-helical fold, termed the death domain (DD) …

We show here that nerve growth factor (NGF), the canonical neurotrophic factor, is
synthesized and released by breast cancer cells. High levels of NGF transcript and protein …

Abstract p75 NTR, the common receptor for both neurotrophins and proneurotrophins, has
been widely studied because of its role in many tissues, including the nervous system. More …

One of the major challenges for cancer therapeutics is the resistance of many tumor cells to
induction of cell death due to pro-survival signaling in the cancer cells. Here we review the …