In patients with renal diseases characterized by proteinuria, the initial insult to the kidney is
usually followed by a progressive decline in the glomerular filtration rate. This decline has …

The endothelin system consists of two G-protein-coupled receptors, three peptide ligands,
and two activating peptidases. Its pharmacological complexity is reflected by the diverse …

In the present study, we examined the hypothesis that dynamic characteristics of flow
modulate the production of vasoactive mediators, namely nitric oxide (NO) and endothelin-1 …

Among the several theories on the pathophysiology of progressive nephropathies [1—41,
the most convincing one [1, 2] suggests that the initial reduction in nephron number …

The endothelins are a family of endothelium-derived peptides that possess characteristically
sustained vasoconstrictor properties. Endothelin-1 appears to be the predominant member …

The human endothelin-1 (ET-1) gene under the control of its natural promoter was
transferred into the germline of mice. The transgene was expressed predominantly in the …

Endothelin-1 (ET-1) is a 21-amino acid peptide that potently modulates renal function. ET-1
is produced by, and binds to, most renal cell types. ET-1 exerts a wide range of biologic …

Overcome the toughest clinical challenges in nephrology with the new 9th edition of
Brenner/Rector's The Kidney! A brand-new editorial team of Drs. Maarten W. Taal, Glenn M …

The incidence of chronic kidney disease (CKD) is increasing worldwide. Cardiovascular
disease (CVD) is strongly associated with CKD and constitutes one of its major causes of …

Progression to renal parenchymal damage and end-stage renal disease, which seems to be
largely independent of the initial insult, is the final common pathway for chronic, proteinuric …