Polymeric nanoparticles in gene therapy: New avenues of design and optimization for delivery applications

R Rai, S Alwani, I Badea - Polymers, 2019 - mdpi.com
The field of polymeric nanoparticles is quickly expanding and playing a pivotal role in a wide
spectrum of areas ranging from electronics, photonics, conducting materials, and sensors to …

Endosomal escape pathways for delivery of biologicals

AK Varkouhi, M Scholte, G Storm, HJ Haisma - Journal of Controlled …, 2011 - Elsevier
Despite continuous improvements in delivery systems, the development of methods for
efficient and specific delivery of targeted therapeutic agents still remains an issue in …

pH-and ion-sensitive polymers for drug delivery

T Yoshida, TC Lai, GS Kwon, K Sako - Expert opinion on drug …, 2013 - Taylor & Francis
Introduction: Drug delivery systems (DDSs) are important for effective, safe, and convenient
administration of drugs. pH-and ion-responsive polymers have been widely employed in …

Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers

P Midoux, C Pichon, JJ Yaouanc… - British journal of …, 2009 - Wiley Online Library
DNA/cationic lipid (lipoplexes), DNA/cationic polymer (polyplexes) and DNA/cationic
polymer/cationic lipid (lipopolyplexes) electrostatic complexes are proposed as non‐viral …

Peptide-based biopolymers in biomedicine and biotechnology

D Chow, ML Nunalee, DW Lim, AJ Simnick… - Materials Science and …, 2008 - Elsevier
Peptides are emerging as a new class of biomaterials due to their unique chemical,
physical, and biological properties. The development of peptide-based biomaterials is …

Self-assembled quantum dot− peptide bioconjugates for selective intracellular delivery

JB Delehanty, IL Medintz, T Pons, FM Brunel… - Bioconjugate …, 2006 - ACS Publications
We demonstrate the use of self-assembled luminescent semiconductor quantum dot (QD)−
peptide bioconjugates for the selective intracellular labeling of several eukaryotic cell lines …

Protein-based block copolymers

OS Rabotyagova, P Cebe, DL Kaplan - Biomacromolecules, 2011 - ACS Publications
Advances in genetic engineering have led to the synthesis of protein-based block
copolymers with control of chemistry and molecular weight, resulting in unique physical and …

Protein‐engineered functional materials

Y Wang, P Katyal, JK Montclare - Advanced Healthcare …, 2019 - Wiley Online Library
Proteins are versatile macromolecules that can perform a variety of functions. In the past
three decades, they have been commonly used as building blocks to generate a range of …

Recombinant protein-based polymers for advanced drug delivery

JL Frandsen, H Ghandehari - Chemical Society Reviews, 2012 - pubs.rsc.org
Advances in recombinant techniques have led to the development of genetically engineered
polymers with exquisite control over monomer sequence and polymer length. The ability to …

The multifaceted histidine-based carriers for nucleic acid delivery: advances and challenges

J He, S Xu, AJ Mixson - Pharmaceutics, 2020 - mdpi.com
Histidines incorporated into carriers of nucleic acids may enhance the extracellular stability
of the nanoparticle, yet aid in the intracellular disruption of the nanoparticle, enabling the …