Structurally dynamic hydrogels for biomedical applications: pursuing a fine balance between macroscopic stability and microscopic dynamics

K Zhang, Q Feng, Z Fang, L Gu, L Bian - Chemical Reviews, 2021 - ACS Publications
Owing to their unique chemical and physical properties, hydrogels are attracting increasing
attention in both basic and translational biomedical studies. Although the classical hydrogels …

Metalloproteinases and their inhibitors: potential for the development of new therapeutics

M Raeeszadeh-Sarmazdeh, LD Do, BG Hritz - Cells, 2020 - mdpi.com
The metalloproteinase (MP) family of zinc-dependent proteases, including matrix
metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs), and a disintegrin …

Treatment with mesenchymal stem cell‐derived nanovesicle‐containing gelatin methacryloyl hydrogels alleviates osteoarthritis by modulating chondrogenesis and …

L Pang, H Jin, Z Lu, F Xie, H Shen, X Li… - Advanced …, 2023 - Wiley Online Library
Osteoarthritis is a degenerative disorder that can severely affect joints, and new treatment
strategies are urgently needed. Administration of mesenchymal stem cell (MSC)‐derived …

[HTML][HTML] Smart dental materials for antimicrobial applications

C Montoya, L Roldan, M Yu, S Valliani, C Ta, M Yang… - Bioactive Materials, 2023 - Elsevier
Smart biomaterials can sense and react to physiological or external environmental stimuli
(eg, mechanical, chemical, electrical, or magnetic signals). The last decades have seen …

Hybrid gelatin hydrogels in nanomedicine applications

B Salahuddin, S Wang, D Sangian… - ACS Applied Bio …, 2021 - ACS Publications
Gelatin based hydrogels are often incorporated with supporting materials such as chitosan,
poly (vinyl alcohol), alginate, carbon nanotubes, and hyaluronic acid. These hybrid materials …

Highly tunable bioactive fiber-reinforced hydrogel for guided bone regeneration

N Dubey, JA Ferreira, A Daghrery, Z Aytac, J Malda… - Acta biomaterialia, 2020 - Elsevier
One of the most damaging pathologies that affects the health of both soft and hard tissues
around the tooth is periodontitis. Clinically, periodontal tissue destruction has been …

Biotin–Avidin System-Based Delivery Enhances the Therapeutic Performance of MSC-Derived Exosomes

D Deng, X Li, JJ Zhang, Y Yin, Y Tian, D Gan, R Wu… - ACS …, 2023 - ACS Publications
Exosomes (EXs) shed by mesenchymal stem cells (MSCs) are potent therapeutic agents
that promote wound healing and regeneration, but when used alone in vivo, their …

A novel injectable piezoelectric hydrogel for periodontal disease treatment

L Roldan, C Montoya, V Solanki, KQ Cai… - … Applied Materials & …, 2023 - ACS Publications
Periodontal disease is a multifactorial, bacterially induced inflammatory condition
characterized by the progressive destruction of periodontal tissues. The successful …

Injectable “nano-micron” combined gene-hydrogel microspheres for local treatment of osteoarthritis

B Li, F Wang, F Hu, T Ding, P Huang, X Xu, J Liang… - NPG Asia …, 2022 - nature.com
Sustained and controllable local gene therapy is a potential method for treating osteoarthritis
(OA) through the delivery of therapeutic microRNAs (miRNAs) to targeted cells. However …

Gelatin methacryloyl hydrogel as an injectable scaffold with multi-therapeutic effects to promote antimicrobial disinfection and angiogenesis for regenerative …

N Dubey, JS Ribeiro, Z Zhang, J Xu… - Journal of Materials …, 2023 - pubs.rsc.org
Regenerative endodontics represents a paradigm shift in dental pulp therapy for necrotic
young permanent teeth. However, there are still challenges associated with attaining …