Aberrant adenosine diphosphate-ribose (ADP)-ribosylation of proteins and nucleic acids is
associated with multiple disease processes such as infections and chronic inflammatory …

During Trypanosoma cruzi infection, macrophages phagocytose parasites and remove
apoptotic cells through efferocytosis. While macrophage 1 (M1) produces proinflammatory …

Inflammasomes are large protein complexes that, once activated, initiate inflammatory
responses by activating the caspase-1 protease. They play pivotal roles in host defense …

Chagas disease is a parasitic infection caused by the protozoan Trypanosoma cruzi. One of
the complications of the disease is the infection of the central nervous system (CNS), as it …

Vertical transmission of Trypanosoma cruzi (T. cruzi) become a globalized health problem
accounting for 22% of new cases of Chagas disease (CD). Congenital infection is now …

Introduction Toxoplasma gondii is the etiologic agent of toxoplasmosis, a disease that affects
about one-third of the human population. Most infected individuals are asymptomatic, but …

Considering the extensive and widespread impact on individuals, cancer can presently be
categorized as a pandemic. In many instances, the development of tumors has been linked …

Simple Summary Many different media have been used to grow protozoa parasites, which
can be classified into two main categories: biphasic and liquid. All major biphasic media …

During cell invasion, large Extracellular Vesicle (lEV) release from host cells was dose‐
dependently triggered by Trypanosoma cruzi metacyclic trypomastigotes (Mtr). This lEV …

Background Chagas cardiomyopathy (ChCM) is a severe form of Chagas disease and a
major cause of cardiovascular morbidity and mortality. The dysregulation of the immune …