Alzheimer's disease (AD) is the most common cause of dementia in elderly people;
currently, there is no efficient treatment. Considering the increase in life expectancy …

In the last years, traditional natural products have been the center of attention for the
scientific community and exploration of their therapeutic abilities is proceeding permanently …

Introduction Neuroinflammation is one of the major pathogeneses in Alzheimer's disease
(AD) and mainly involves abnormal inflammatory activation of microglia by multiple …

Abstract Alzheimer's disease (AD), the major form of neurodegenerative diseases that can
severely impede normal cognitive function, makes it one of the most common fatal diseases …

Alzheimer's disease (AD) is a debilitating neurodegenerative disorder, characterized by
memory deficit and dementia. AD is considered a multifactorial disorder where multiple …

Increased oxidative stress and acetylcholinesterase (AChE) activity are key pathological
characters contributing to the memory disorders. Thus, drugs targeting both oxidative stress …

Previously, we demonstrated that palmatine (PALM)–an isoquinoline alkaloid from Berberis
sibrica radix, exerted antiseizure activity in the pentylenetetrazole (PTZ)-induced seizure …

The cerebellum is crucial for both motor and nonmotor functions. Alzheimer's disease (AD),
alongside other dementias such as vascular dementia (VaD), Lewy body dementia (DLB) …

NLRP3 inflammasomes-mediated proinflammatory response and mitochondrial dysfunction
play a critical role in the etiology and pathogenesis of Parkinson's disease. Negative …

Objective: The PRAS40 is an essential inhibitory subunit of the mTORC1 complex, which
regulates autophagy. It has been suggested that Erxian Decoction (EXD) could treat spinal …