Neuropeptides: Potential neuroprotective agents in ischemic injury
Aim Ischemic damage to the brain is linked to an increased rate of morbidity and mortality
worldwide. In certain parts of the world, it remains a leading cause of mortality and the …
worldwide. In certain parts of the world, it remains a leading cause of mortality and the …
Review on the protective effects of PACAP in models of neurodegenerative diseases in vitro and in vivo
D Reglodi, P Kiss, A Lubics… - Current pharmaceutical …, 2011 - ingentaconnect.com
Pituitary adenylate cyclase activating polypeptide (PACAP) is a pleiotropic and
multifunctional peptide exerting its effects via 3 main receptors (PAC1, VPAC1 and VPAC2) …
multifunctional peptide exerting its effects via 3 main receptors (PAC1, VPAC1 and VPAC2) …
Tunable surface charge enables the electrostatic adsorption-controlled release of neuroprotective peptides from a hydrogel–nanoparticle drug delivery system
We exploit the electrostatic interactions between the positively charged neuroprotective
peptide, pituitary adenylate cyclase-activating polypeptide (PACAP), and negatively charged …
peptide, pituitary adenylate cyclase-activating polypeptide (PACAP), and negatively charged …
Protective effects of PACAP in peripheral organs
Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide widely
distributed in the nervous system, where it exerts strong neuroprotective effects. PACAP is …
distributed in the nervous system, where it exerts strong neuroprotective effects. PACAP is …
VIP and PACAP: recent insights into their functions/roles in physiology and disease from molecular and genetic studies
TW Moody, T Ito, N Osefo… - Current Opinion in …, 2011 - journals.lww.com
PACAP/VIP as well as their three classes of receptors are important in many physiological/
pathophysiological processes, some of which are identified in these studies using knockout …
pathophysiological processes, some of which are identified in these studies using knockout …
PACAP is an endogenous protective factor—insights from PACAP-deficient mice
D Reglodi, P Kiss, K Szabadfi, T Atlasz… - Journal of Molecular …, 2012 - Springer
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a widespread neuropeptide
with a diverse array of biological functions. Not surprisingly, the lack of endogenous PACAP …
with a diverse array of biological functions. Not surprisingly, the lack of endogenous PACAP …
Delayed pituitary adenylate cyclase–activating polypeptide delivery after brain stroke improves functional recovery by inducing M2 microglia/macrophage polarization
C Brifault, M Gras, D Liot, V May, D Vaudry, O Wurtz - Stroke, 2015 - Am Heart Assoc
Background and Purpose—Until now, except thrombolysis, the therapeutical strategies
targeting the acute phase of cerebral ischemia have been proven ineffective, and no …
targeting the acute phase of cerebral ischemia have been proven ineffective, and no …
Protective effects of PACAP in ischemia
D Reglodi, A Vaczy, E Rubio-Beltran… - The Journal of …, 2018 - Springer
Pituitary adenylate cyclase activating polypeptide (PACAP) is an ubiquitous peptide
involved, among others, in neurodevelopment, neuromodulation, neuroprotection …
involved, among others, in neurodevelopment, neuromodulation, neuroprotection …
PACAP as a neuroprotective factor in ischemic neuronal injuries
S Shioda, T Nakamachi - Peptides, 2015 - Elsevier
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 27-or 38-amino acid
neuropeptide, which belongs to the vasoactive intestinal polypeptide/glucagon/secretin …
neuropeptide, which belongs to the vasoactive intestinal polypeptide/glucagon/secretin …
Pituitary adenylate cyclase-activating polypeptide: focus on structure-activity relationships of a neuroprotective peptide
S Bourgault, D Vaudry, A Dejda… - Current medicinal …, 2009 - ingentaconnect.com
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 38-amino acid peptide that
was initially isolated from hypothalamus extracts on the basis of its ability to stimulate the …
was initially isolated from hypothalamus extracts on the basis of its ability to stimulate the …