Roles of F-box proteins in cancer

Z Wang, P Liu, H Inuzuka, W Wei - Nature reviews Cancer, 2014 - nature.com
F-box proteins, which are the substrate-recognition subunits of SKP1–cullin 1–F-box protein
(SCF) E3 ligase complexes, have pivotal roles in multiple cellular processes through …

Update on otitis media–prevention and treatment

A Qureishi, Y Lee, K Belfield, JP Birchall… - Infection and drug …, 2014 - Taylor & Francis
Acute otitis media and otitis media with effusion are common childhood disorders, a source
of significant morbidity, and a leading cause of antibiotic prescription in primary health care …

Chronic otitis media

GG Browning, J Weir, G Kelly… - … and Head and Neck …, 2018 - taylorfrancis.com
From the early 1980s onwards, otoendoscopy was increasingly used to inspect and
diagnose middle ear disease, particularly residual disease after canal wall up …

Understanding the aetiology and resolution of chronic otitis media from animal and human studies

MF Bhutta, RB Thornton, LAS Kirkham… - Disease models & …, 2017 - journals.biologists.com
Inflammation of the middle ear, known clinically as chronic otitis media, presents in different
forms, such as chronic otitis media with effusion (COME; glue ear) and chronic suppurative …

Circ-RBMS1 knockdown alleviates CSE-induced apoptosis, inflammation and oxidative stress via up-regulating FBXO11 through miR-197-3p in 16HBE cells

D Qiao, C Hu, Q Li, J Fan - International Journal of Chronic …, 2021 - Taylor & Francis
Background Emerging evidence has reported that circular RNAs (circRNAs) are aberrantly
expressed and act as significant regulators in pathological processes of chronic obstructive …

Panel 1: Epidemiology, natural history, and risk factors

HJ Hoffman, KA Daly, KE Bainbridge… - … –Head and Neck …, 2013 - Wiley Online Library
Background The First International Symposium on Recent Advances in Otitis Media (OM)
with Effusion was held in Columbus, Ohio, in 1975. The symposium has been organized in …

Genome-wide association study to identify the genetic determinants of otitis media susceptibility in childhood

MS Rye, NM Warrington, ESH Scaman… - PloS one, 2012 - journals.plos.org
Background Otitis media (OM) is a common childhood disease characterised by middle ear
inflammation and effusion. Susceptibility to recurrent acute OM (rAOM;≥ 3 episodes of AOM …

Genetic susceptibility to otitis media in childhood

MS Rye, JM Blackwell, SE Jamieson - The Laryngoscope, 2012 - Wiley Online Library
Otitis media (OM) is a common disease in early childhood characterized by inflammation of
the middle ear cavity. Heritability studies suggest that there is a substantial genetic …

HIF–VEGF Pathways Are Critical for Chronic Otitis Media in Junbo and Jeff Mouse Mutants

MT Cheeseman, HE Tyrer, D Williams, TA Hough… - PLoS …, 2011 - journals.plos.org
Otitis media with effusion (OME) is the commonest cause of hearing loss in children, yet the
underlying genetic pathways and mechanisms involved are incompletely understood …

Unraveling the genetics of otitis media: from mouse to human and back again

MS Rye, MF Bhutta, MT Cheeseman, D Burgner… - Mammalian …, 2011 - Springer
Otitis media (OM) is among the most common illnesses of early childhood, characterised by
the presence of inflammation in the middle ear cavity. Acute OM and chronic OM with …