Erythropoiesis occurs mostly in bone marrow and ends in blood stream. Mature red blood
cells are generated from multipotent hematopoietic stem cells, through a complex maturation …

Normal hematopoiesis requires the accurate orchestration of lineage-specific patterns of
gene expression at each stage of development, and epigenetic regulators play a vital role …

This article reviews the regulation of production of RBCs at several levels. We focus on the
regulated expansion of burst-forming unit-erythroid erythroid progenitors by glucocorticoids …

Chicken erythrocytes are nucleated cells often considered to be transcriptionally inactive,
although the epigenetic changes and chromatin remodeling that would mediate …

A characteristic feature of terminal erythropoiesis in mammals is extrusion of the highly
condensed nucleus out of the cytoplasm. Other vertebrates, including fish, reptiles …

In all vertebrates, the cell nucleus becomes highly condensed and transcriptionally inactive
during the final stages of red cell biogenesis. Enucleation, the process by which the nucleus …

Histone deacetylases (HDACs) are a group of enzymes that catalyze the removal of acetyl
groups from histone and nonhistone proteins. HDACs have been shown to have diverse …

Cancer immunotherapy using immune-checkpoint inhibitors (ICIs) has revolutionized the
field of cancer treatment; however, ICI efficacy is constrained by progressive dysfunction of …

Vesicular trafficking and selective autophagy have emerged as central processes in cellular
remodeling. In reticulocytes, this includes enucleation and the elimination of all membrane …

Erythroblasts possess unique characteristics as they undergo differentiation from
hematopoietic stem cells. During terminal erythropoiesis, these cells incorporate large …