Background The objective of this study was to evaluate and present evidence from animal
and human clinical studies on associations between dental caries and systemic diseases …

Collagen is the most abundant structural protein in the body and the main component of the
extracellular matrix of most tissues, including dentine and periodontal tissues. Despite the …

Although changes in gut microbiome have been associated with the development of T2D
and its complications, the role of the gut virome remains largely unknown. Here, we …

The US prevalence of nonalcoholic fatty liver disease (NAFLD) is 30.6% and increasing.
NAFLD shares some risk factors with periodontitis and dental caries. We explored the …

Streptococcus mutans is known to be a major causative agent of dental caries, and strains
expressing the cell surface collagen-binding Cnm protein contribute to the development of …

A relationship between IgA nephropathy (IgAN) and bacterial infection has been suspected.
As IgAN is a chronic disease, bacteria that could cause chronic infection in oral areas might …

Background Non-alcoholic steatohepatitis (NASH) has become a major public health issue
as one of the leading causes of liver disease and transplantation worldwide. The …

The mechanisms underlying immunoglobulin A nephropathy (IgAN), the most common
chronic form of primary glomerulonephritis, remain poorly understood. Streptococcus …

Abstract inflammatory bowel diseases (iBDs) are chronic, relapsing inflammatory diseases
characterized by exacerbations and remissions of the gastrointestinal tract, clinically …

Streptococcus mutans is a major pathogen of human dental caries. Strains harbouring the
cnm gene, which encodes Cnm, a collagen-binding protein, contribute to the development of …