Glaucoma is one of the leading causes of vision impairment worldwide. In order to further
understand the molecular pathobiology of this disease and to develop better therapies …

Glaucoma is the result of the gradual death of retinal ganglion cells (RGCs) whose axons
form the optic nerve. Elevated intraocular pressure (IOP) is a major risk factor that …

Primary open angle glaucoma (POAG) is the most common form of glaucoma and the 2nd
most common cause of irreversible vision loss in the United States. Nearly 67 million people …

Primary open-angle glaucoma (POAG) represents the leading cause of irreversible
blindness worldwide and is a multifactorial, chronic neurodegenerative disease …

Background Elevated transforming growth factor (TGF)-β2 in aqueous humor (AH) has been
suggested to contribute to trabecular meshwork (TM) fibrosis and intraocular pressure (IOP) …

RNA-interference-based mechanisms, especially the use of small interfering RNAs
(siRNAs), have been under investigation for the treatment of several ailments and have …

Purpose: The effects of aqueous mediators possibly increasing the outflow resistance,
transforming growth factor-β1 (TGF-β1), TGF-β2, autotaxin (ATX), and lysophosphatidic acid …

To examine whether autotaxin (ATX) in the aqueous humor causes elevated intraocular
pressure (IOP) in patients with Posner-Schlossman syndrome (PSS). ATX and transforming …

Purpose: Fibronectin fibrillogenesis is an integrin-mediated process that may contribute to
the pathogenesis of primary open-angle glaucoma (POAG). Here, we examined the effects …

Glaucoma is a lifelong disease with elevated intraocular pressure (IOP) as the main risk
factor, and reduction of IOP remains the major treatment for this disease. However, current …