Resolution of inflammation: An organizing principle in biology and medicine

D Panigrahy, MM Gilligan, CN Serhan… - Pharmacology & …, 2021 - Elsevier
The resolution of inflammation has emerged as a critical endogenous process that protects
host tissues from prolonged or excessive inflammation that can become chronic. Failure of …

Resolution of chronic inflammatory disease: universal and tissue-specific concepts

G Schett, MF Neurath - Nature communications, 2018 - nature.com
Inflammation and its resolution is under-studied in medicine despite being essential for
understanding the development of chronic inflammatory disease. In this review article, we …

Carcinogenesis: Failure of resolution of inflammation?

A Fishbein, BD Hammock, CN Serhan… - Pharmacology & …, 2021 - Elsevier
Inflammation in the tumor microenvironment is a hallmark of cancer and is recognized as a
key characteristic of carcinogens. However, the failure of resolution of inflammation in …

Inflammation in cystic fibrosis: An update

EA Roesch, DP Nichols, JF Chmiel - Pediatric pulmonology, 2018 - Wiley Online Library
Inflammation plays a critical role in cystic fibrosis (CF) lung pathology and disease
progression making it an active area of research and important therapeutic target. In this …

Integrative physiology of pneumonia

LJ Quinton, AJ Walkey, JP Mizgerd - Physiological reviews, 2018 - journals.physiology.org
Pneumonia is a type of acute lower respiratory infection that is common and severe. The
outcome of lower respiratory infection is determined by the degrees to which immunity is …

Therapeutic potential of omega-3 fatty acid-derived epoxyeicosanoids in cardiovascular and inflammatory diseases

WH Schunck, A Konkel, R Fischer… - Pharmacology & …, 2018 - Elsevier
Numerous benefits have been attributed to dietary long-chain omega-3 polyunsaturated fatty
acids (n-3 LC-PUFAs), including protection against cardiac arrhythmia, triglyceride-lowering …

Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium

HH Dar, YY Tyurina… - The Journal of …, 2019 - Am Soc Clin Investig
Ferroptosis is a death program executed via selective oxidation of arachidonic acid–
phosphatidylethanolamines (AA-PE) by 15-lipoxygenases. In mammalian cells and tissues …

Role of specialized pro-resolving lipid mediators in pulmonary inflammation diseases: Mechanisms and development

A Yang, Y Wu, G Yu, H Wang - Respiratory Research, 2021 - Springer
Inflammation is an essential mechanism of various diseases. The development and
resolution of inflammation are complex immune-modulation processes which induce the …

Resolution of chronic inflammation and cancer

G Tezcan, N Yakar, H Hasturk, TE Van Dyke… - Periodontology …, 2024 - Wiley Online Library
Chronic inflammation poses challenges to effective cancer treatment. Although anti‐
inflammatory therapies have shown short‐term benefits, their long‐term implications may be …

Enhancing cancer immunotherapy via inhibition of soluble epoxide hydrolase

AG Kelly, W Wang, E Rothenberger… - Proceedings of the …, 2024 - National Acad Sciences
Cancer therapy, including immunotherapy, is inherently limited by chronic inflammation-
induced tumorigenesis and toxicity within the tumor microenvironment. Thus, stimulating the …