T cell immunoglobulin and mucin domain 3 (TIM-3) was originally found to be expressed on
the surface of Th1 cells, acting as a negative regulator and binding to the ligand galectin-9 to …

The TIM (T cell/transmembrane, immunoglobulin, and mucin) gene family plays a critical role
in regulating immune responses, including allergy, asthma, transplant tolerance …

A major component of COVID-19 severe respiratory syndrome is the patient's immune
response to the SARS-CoV-2 virus and the consequential multi-organ inflammatory …

In the last two years, clinical trials with blocking antibodies to the negative checkpoint
regulators CTLA-4 and PD-1 have rekindled the hope for cancer immunotherapy. Multiple …

The immune system is capable of distinguishing between danger-and non-danger signals,
thus inducing either an appropriate immune response against pathogens and cancer or …

T cell/transmembrane, Ig, and mucin (TIM) proteins, identified using a congenic mouse
model of asthma, critically regulate innate and adaptive immunity. TIM-1 and TIM-4 are …

Tim-3 was initially identified on activated Th1, Th17, and Tc1 cells and induces T cell death
or exhaustion after binding to its ligand, Gal-9. The observed relationship between …

BACKGROUND & AIMS: T cell immunoglobulin-and mucin-domain-containing molecule-3
(Tim-3) has been shown to influence autoimmune diseases; however, its function in viral …

Inflammation is closely related to the extent of damage following cerebral ischaemia, and the
targeting of this inflammation has emerged as a promising therapeutic strategy. Here, we …

T cell (or transmembrane) immunoglobulin and mucin domain protein 3 (Tim-3) has
attracted significant attention as a novel immune checkpoint receptor (ICR) on chronically …