ABSTRACT E-cadherin is the main component of epithelial adherens junctions (AJs), which
play a crucial role in the maintenance of stable cell–cell adhesion and overall tissue …

Claudin-low breast cancer (CLBC) is a subgroup of breast cancer discovered at the
molecular level in 2007. Claudin is one of the primary proteins that make up tight junctions …

The barrier and fence functions of the claudin protein family are fundamental to tissue
integrity and human health. Increasing evidence has linked claudins to signal transduction …

Background Triple-negative breast cancers (TNBC) have a relatively poor prognosis and
responses to targeted therapies. Between 25 and 39% of TNBCs are claudin-low, a poorly …

Stratifying breast cancer into specific molecular or histologic subtypes aids in therapeutic
decision-making and predicting outcomes; however, these subtypes may not be as distinct …

In breast cancers, aberrant activation of the RAS/MAPK pathway is strongly associated with
mesenchymal features and stemness traits, suggesting an interplay between this mitogenic …

Simple Summary For many decades, the cellular and molecular mechanisms that
orchestrate the differentiation of epithelial subtypes in the mammary gland have been a …

Keloids are pathological fibroproliferative scars resulting from abnormal collagen deposition
within and beyond the margins of the initial cutaneous insult. Keloids negatively impact QOL …

Histone deacetylase inhibitors, such as suberoylanilide hydroxamic acid (SAHA), possess
great therapeutic value for triple-negative breast cancer patients. However, their inherent …

Cytochrome P4501B1 (CYP1B1) is elevated in breast cancer. Studies indicate a relationship
between CYP1B1 and aggressive cancer phenotypes. Here, we report on in vitro studies in …