The extracellular matrix (ECM) plays an important role in determining cell and organ
function:(1) it is an organizing substrate that provides tissue tensile strength;(2) it anchors …

The pelvis performs two major functions for terrestrial mammals. It provides somewhat rigid
support for muscles engaged in locomotion and, for females, it serves as the birth canal. The …

We previously quantified frailty in aged mice with frailty index (FI) that used specialized
equipment to measure health parameters. Here we developed a simplified, noninvasive …

In pelvic organ prolapse (POP) patients, the uterus, bladder and/or rectum descends into
vagina due to weakened support tissues. High recurrence rates after POP surgery suggest …

Needles for percutaneous biopsies of tumour tissue can be guided by ultrasound or
computed tomography. However, despite best imaging practices and operator experience …

Edited and authored by some of the most respected figures in the field, Urogynecology and
Reconstructive Pelvic Surgery presents definitive, state-of-the-art guidance on every aspect …

Pelvic organ prolapse (POP) is a disabling disorder in women characterized by a loss of
pelvic floor support leading to the herniation of the uterus into or through the vagina. POP is …

Objective To define the impact of prolapse mesh on the biomechanical properties of the
vagina by comparing the prototype Gynemesh PS (Ethicon) to two new‐generation lower …

Background: Pelvic organ prolapse (POP) is defined as the descent of one or more of the
pelvic structures into the vagina and includes uterine, vaginal vault, and anterior or posterior …

Introduction and hypothesis This manuscript is the International Urogynecology Consultation
(IUC) on pelvic organ prolapse (POP) chapter one, committee three, on the Pathophysiology …