The Monod-Wyman-Changeux (MWC) model was conceived in 1965 to account for the
signal transduction and cooperative properties of bacterial regulatory enzymes and …

Cys-loop receptors are membrane-spanning neurotransmitter-gated ion channels that are
responsible for fast excitatory and inhibitory transmission in the peripheral and central …

Defects in iron absorption and utilization lead to iron deficiency and overload disorders.
Adult mammals absorb iron through the duodenum, whereas embryos obtain iron through …

Exactly 50 years ago, biochemists raised the question of the mechanism of the
conformational change that mediates “allosteric” interactions between regulatory sites and …

The neurotransmitter acetylcholine (ACh) exerts its effects on the central nervous system
(CNS) and peripheral nervous system (PNS) through two distinct types of receptors: the …

Nicotinic ACh receptors (nAChRs) can undergo desensitization, a reversible reduction in
response during sustained agonist application. Although the mechanism of desensitization …

A critical event in the history of biological chemistry was the chemical identification of the first
neurotransmitter receptor, the nicotinic acetylcholine receptor. Disciplines as diverse as …

The fine structure of ion‐channel activations by junctional nicotinic receptors in adult frog
muscle fibres has been investigated. The agonists used were acetylcholine (ACh) …

Orthologs of the pentameric receptor channels that mediate fast synaptic transmission in the
central and peripheral nervous systems have been found in several bacterial species and in …

The nicotinic acetylcholine (ACh) receptors and the other neurotransmitter-gated ion
channels have key roles in fast synaptic transmission throughout the nervous system. These …