C–H activation

T Rogge, N Kaplaneris, N Chatani, J Kim… - Nature Reviews …, 2021 - nature.com
Transition metal-catalysed C–H activation has emerged as an increasingly powerful platform
for molecular syntheses, enabling applications to natural product syntheses, late-stage …

Organic synthesis with the most abundant transition metal–iron: from rust to multitasking catalysts

S Rana, JP Biswas, S Paul, A Paik… - Chemical Society Reviews, 2021 - pubs.rsc.org
In industries and academic laboratories, several late transition metal-catalyzed prerequisite
reactions are widely performed during single and multistep synthesis. However, besides the …

3d transition metals for C–H activation

P Gandeepan, T Müller, D Zell, G Cera… - Chemical …, 2018 - ACS Publications
C–H activation has surfaced as an increasingly powerful tool for molecular sciences, with
notable applications to material sciences, crop protection, drug discovery, and …

Advancing the logic of chemical synthesis: C− H activation as strategic and tactical disconnections for C− C bond construction

NYS Lam, K Wu, JQ Yu - Angewandte Chemie, 2021 - Wiley Online Library
The design of synthetic routes by retrosynthetic logic is decisively influenced by the
transformations available. Transition‐metal‐catalyzed C− H activation has emerged as a …

[HTML][HTML] A comprehensive overview of directing groups applied in metal-catalysed C–H functionalisation chemistry

C Sambiagio, D Schönbauer, R Blieck… - Chemical Society …, 2018 - pubs.rsc.org
The present review is devoted to summarizing the recent advances (2015–2017) in the field
of metal-catalysed group-directed C–H functionalisation. In order to clearly showcase the …

Construction of Quaternary Stereocenters by Palladium‐Catalyzed Carbopalladation‐Initiated Cascade Reactions

Y Ping, Y Li, J Zhu, W Kong - … Chemie International Edition, 2019 - Wiley Online Library
The enantioselective synthesis of molecules containing quaternary stereocenters is a field of
intense research interest and development. Among the known organic transformations …

[HTML][HTML] The crucial role of silver (i)-salts as additives in C–H activation reactions: overall analysis of their versatility and applicability

RL de Carvalho, EBT Diogo, SL Homölle… - Chemical Society …, 2023 - pubs.rsc.org
Transition-metal catalyzed C–H activation reactions have been proven to be useful
methodologies for the assembly of synthetically meaningful molecules. This approach bears …

Late‐stage peptide diversification by position‐selective C− H activation

W Wang, MM Lorion, J Shah, AR Kapdi… - Angewandte Chemie …, 2018 - Wiley Online Library
The late‐stage modification of structurally complex peptides bears great potential for drug
discovery, crop protection, and the pharmaceutical industry, among others. Whereas …

Recent advances in transition metal-catalyzed heteroannulative difunctionalization of alkenes via C–H activation for the synthesis of heterocycles

J Liu, X Xiao, Y Lai, Z Zhang - Organic Chemistry Frontiers, 2022 - pubs.rsc.org
Heterocyclic compounds are the fundamental structural motifs distributed in natural
products, pharmaceuticals and biologically active compounds. Thus, there is increasing …

[HTML][HTML] sp 3 C–H activation via exo-type directing groups

Y Xu, G Dong - Chemical Science, 2018 - pubs.rsc.org
The application of exo-type directing groups (DGs) has led to the discovery of a wide range
of novel C (sp3)–H activation methods, which allow efficient and site-selective …