The ubiquitin proteasome system (UPS) degrades individual proteins in a highly regulated
fashion and is responsible for the degradation of misfolded, damaged, or unneeded cellular …

The life of every organism is dependent on the fine-tuned mechanisms of protein synthesis
and breakdown. The degradation of most intracellular proteins is performed by the ubiquitin …

Abstract Ubiquitin Proteasome System (UPS) is an adaptable and finely tuned system that
sustains proteostasis network under a large variety of physiopathological conditions. Its …

Ortholog protein complexes are responsible for equivalent functions in different organisms.
However, during evolution, each organism adapts to meet its physiological needs and the …

Neurodegenerative diseases are a class of age-associated proteopathies characterized by
the accumulation of misfolded and/or aggregation-prone proteins. This imbalance has been …

Accumulating evidence arising from numerous clinical studies indicate that assembled and
functional 20S proteasome complexes circulate freely in plasma. Elevated levels of this core …

The proteasome is a well-identified therapeutic target for cancer treatment. It acts as the
main protein degradation system in the cell and degrades key mediators of cell growth …

Proline-and arginine-rich peptide PR11 is an allosteric inhibitor of 20S proteasome. We
modified its sequence inter alia by introducing HbYX, RYX, or RHbX C-terminal extensions …

Alzheimer's Diseases (AD) is characterized by the accumulation of amyloid deposits of Aβ
peptide in the brain. Besides genetic background, the presence of other diseases and an …

The proteasome degrades proteins, which is essential for cellular homeostasis. Ubiquitin
independent proteolysis degrades highly disordered and misfolded proteins. A decline of …