This brief essay consists of a few “exciting stories” devoted to relations within a metal-
complex catalyst between a metal ion and a coordinated ligand. When, as in the case of a …

Discovery of soluble methane monooxygenase (sMMO) in 1966 aroused enthusiastic
research on dinuclear iron centers, both in biological systems and chemical models. From …

The recently discovered fungal and bacterial polysaccharide monooxygenases (PMOs) are
capable of oxidatively cleaving chitin, cellulose, and hemicelluloses that contain β (1→ 4) …

The increasing demand for the next generation of renewable fuels has driven extensive
research in carbohydrate-active enzymes involved in converting plant biomass to …

The second coordination sphere constitutes a distinguishing factor in the active site to
modulate enzymatic reactivity. To unravel the origin of NO‐to‐N2O reduction activity of non …

The final step in the biosynthesis of the antibiotic chloramphenicol is the oxidation of an aryl-
amine substrate to an aryl-nitro product catalyzed by the N-oxygenase CmlI in three two …

Covering: up to 2017 The participation of non-heme dinuclear iron cluster-containing
monooxygenases in natural product biosynthetic pathways has been recognized only …

Through QM/MM modeling, we discovered that C (sp3)− H β‐hydroxylation in the diiron
hydroxylase CmlA transpires by traceless amine‐assisted O2 activation. Different from the …

A family of dinuclear iron cluster-containing oxygenases that catalyze β-hydroxylation
tailoring reactions in natural product biosynthesis by nonribosomal peptide synthetase …

β-Hydroxylation plays an important role in the nonribosomal peptide biosynthesis of many
important natural products, including bleomycin, chloramphenicol, and the glycopeptide …