Passive mechanical tissue properties are major determinants of myocardial contraction and
relaxation and, thus, shape cardiac function. Tightly regulated, dynamically adapting …

Human pluripotent stem cells (hPSCs), derived from individuals or genetically modified with
disease-related mutations and variants, have revolutionised studies of human disease …

Microphysiological systems (MPS) are drawing increasing interest from academia and from
biomedical industry due to their improved capability to capture human physiology. MPS offer …

The reconstruction of bone defects following bone tumor resection pose significant
challenges, including high risks for tumor recurrence. To address these challenges, we …

The prospective use of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-
CM) for cardiac regenerative medicine strongly depends on the electro-mechanical …

Cardiovascular diseases are the leading cause of death worldwide. Several strategies–
small molecules, gene therapy, surgeries, cardiac rehabilitation–have been developed to …

Cell alignment widely exists in various in vivo tissues and also plays an essential role in the
construction of in vitro models, such as vascular endothelial and myocardial models …

Biophysical cues can facilitate the cardiac differentiation of human pluripotent stem cells
(hPSCs), yet the mechanism is far from established. One of the binary colloidal crystals …

Biofabrication of human tissues has seen a meteoric growth triggered by recent technical
advancements such as human induced pluripotent stem cells (hiPSCs) and additive …

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) represent one of the most
promising ways to treat cardiovascular diseases. High-purity cardiomyocytes (CM) from …