[HTML][HTML] GABAA receptor subtypes and benzodiazepine use, misuse, and abuse
E Engin - Frontiers in Psychiatry, 2023 - frontiersin.org
Benzodiazepines have been in use for over half a century. While they remain highly
prescribed, their unfavorable side-effect profile and abuse liability motivated a search for …
prescribed, their unfavorable side-effect profile and abuse liability motivated a search for …
Neurosteroids (allopregnanolone) and alcohol use disorder: from mechanisms to potential pharmacotherapy
Abstract Alcohol Use Disorder (AUD) is a multifaceted relapsing disorder that is commonly
comorbid with psychiatric disorders, including anxiety. Alcohol exposure produces a …
comorbid with psychiatric disorders, including anxiety. Alcohol exposure produces a …
[HTML][HTML] Genome-wide methylation in alcohol use disorder subjects: implications for an epigenetic regulation of the cortico-limbic glucocorticoid receptors (NR3C1)
Environmental factors, including substance abuse and stress, cause long-lasting changes in
the regulation of gene expression in the brain via epigenetic mechanisms, such as DNA …
the regulation of gene expression in the brain via epigenetic mechanisms, such as DNA …
[HTML][HTML] The lncRNA BDNF-AS is an epigenetic regulator in the human amygdala in early onset alcohol use disorders
Adolescent alcohol drinking is known to contribute to the development and severity of
alcohol use disorders (AUDs) later in adulthood. Recent studies have shown that long non …
alcohol use disorders (AUDs) later in adulthood. Recent studies have shown that long non …
Altered amygdala DNA methylation mechanisms after adolescent alcohol exposure contribute to adult anxiety and alcohol drinking
AJ Sakharkar, EJ Kyzar, DP Gavin, H Zhang, Y Chen… - …, 2019 - Elsevier
Binge drinking during adolescence increases the risk for neuropsychiatric disorders
including alcoholism in adulthood. DNA methylation in post-mitotic neurons is an important …
including alcoholism in adulthood. DNA methylation in post-mitotic neurons is an important …
α6-Containing GABAA receptors: functional roles and therapeutic potentials
GABAA receptors containing the α 6 subunit are highly expressed in cerebellar granule cells
and less abundantly in many other neuronal and peripheral tissues. Here, we for the first …
and less abundantly in many other neuronal and peripheral tissues. Here, we for the first …
Characteristics of amplitude of low-frequency fluctuations in the resting-state functional magnetic resonance imaging of alcohol-dependent patients with depression
F Sun, J Yang, X Liu, G Huang, Z Kong, Y Liu… - Cerebral …, 2023 - academic.oup.com
The high comorbidity of alcohol use disorder and depressive disorder is associated with
poor patient prognosis. The mechanisms underlying this comorbidity, however, are largely …
poor patient prognosis. The mechanisms underlying this comorbidity, however, are largely …
[HTML][HTML] Prenatal ethanol exposure and changes in fetal neuroendocrine metabolic programming
L Liu, Y Wen, Q Ni, L Chen, H Wang - Biological Research, 2023 - Springer
Prenatal ethanol exposure (PEE)(mainly through maternal alcohol consumption) has
become widespread. However, studies suggest that it can cause intrauterine growth …
become widespread. However, studies suggest that it can cause intrauterine growth …
[HTML][HTML] Data-driven study on resting-state functional magnetic resonance imaging during early abstinence of alcohol dependence in male patients and its predictive …
R Deng, X Yang, Y Meng, Y Tao, H Wang, X Li, W Wei… - BMC psychiatry, 2022 - Springer
Background Alcohol dependence is a mental disorder with a high relapse rate. However,
specific neuroimaging biomarkers have not been determined for alcohol dependence and …
specific neuroimaging biomarkers have not been determined for alcohol dependence and …
Dietary Supplementation of Methyl Donor l‐Methionine Alters Epigenetic Modification in Type 2 Diabetes
Scope The aim of the current study is to evaluate whether l‐methionine supplementation (l‐
Met‐S) improves type 2 diabetes‐induced alterations in glucose and lipid metabolism by …
Met‐S) improves type 2 diabetes‐induced alterations in glucose and lipid metabolism by …