In contrast to solid cancers, which often require genetic modifications and complex cellular
reprogramming for effective metastatic dissemination, leukaemic cells uniquely possess the …

Breast cancer cells incorporate the simple sugar alpha-L-fucose (fucose) into glycoproteins
and glycolipids which, in turn, are expressed as part of the malignant phenotype. We have …

Breast cancer metastatic relapse can occur years after therapy, indicating that disseminated
breast cancer cells (BCCs) have a prolonged dormant phase before becoming proliferative …

The glycome acts as an essential interface between cells and the surrounding
microenvironment. However, changes in glycosylation occur in nearly all breast cancers …

Glycosylation of cellular proteins has important impact on their stability and functional
properties, and glycan structures strongly influence cell adhesion. Many enzymes are …

Adhesion of circulating tumor cells to vascular endothelium is mediated by specialized
molecules that are functional under shear forces exerted by hematogenous flow. Endothelial …

Advanced prostate cancer commonly metastasizes to bone, but transit of malignant cells
across the bone marrow endothelium (BMEC) remains a poorly understood step in …

Selectin-mediated interactions in the vasculature promote metastatic spread by facilitating
circulating tumor cell binding to selectin-expressing host cells. Therefore, identifying the …

Dissemination of multiple myeloma into the bone marrow proceeds through sequential steps
mediated by a variety of adhesion molecules and chemokines that eventually results in the …

Sialylation of cell surface glycans plays an essential role in cell–cell interaction and
communication of cells with their microenvironment. Among the tools that have been …