SHP2 (Src homology-2 domain-containing protein tyrosine phosphatase-2) is a non-
receptor protein tyrosine phosphatase that removes tyrosine phosphorylation. Functionally …

Protein tyrosine phosphatase 1B (PTP1B) is an effective target for the treatment of both type
2 diabetes and obesity; however, targeting PTP1B for drug discovery is challenging because …

Protein tyrosine phosphatases (PTPs) are signaling enzymes that control a diverse array of
cellular processes. Malfunction of PTP activity is associated with a number of human …

It is well-established that dynamics are central to protein function; their importance is
implicitly acknowledged in the principles of the Monod, Wyman and Changeux model of …

Allostery is an inherent feature of proteins, but it remains challenging to reveal the
mechanisms by which allosteric signals propagate. A clearer understanding of this intrinsic …

Coordinated tyrosine phosphorylation is essential for signalling pathways regulated by
insulin and leptin. Type 2 diabetes and obesity are characterised by resistance to hormones …

An overwhelming increase in metabolic syndrome, ie, obesity, insulin resistance and
dyslipidemia has led to type 2 or insulin-resistant diabetes mellitus assuming epidemic …

The protein tyrosine phosphatases (PTPs) are now recognized as critical regulators of signal
transduction under normal and pathophysiological conditions. In this analysis we have …

Mimicking nature synthetically: The successful development of multistep stereoselective
syntheses gives access to natural product inspired compound collections having carbo …

Protein tyrosine phosphatases are often exploited and subverted by pathogenic bacteria to
cause human diseases. The tyrosine phosphatase mPTPB from Mycobacterium tuberculosis …