From biology to treatment of monoclonal gammopathies of neurological significance

A Visentin, S Pravato, F Castellani, M Campagnolo… - Cancers, 2022 - mdpi.com
Simple Summary The peripheral nervous systems may be involved by several
hematological diseases ranging from preneoplastic diseases to overt malignancies or …

Paraproteinemic neuropathies

SR Beydoun, L Darki - CONTINUUM: Lifelong Learning in …, 2023 - journals.lww.com
OBJECTIVE Coexistence of polyneuropathy and gammopathy is a common but potentially
challenging situation in clinical practice. This article reviews the clinical, electrophysiologic …

Ultrasensitive assay technology and fluid biomarkers for the evaluation of peripheral nerve disease

R Bellanti, S Keddie, MP Lunn… - Journal of Neurology …, 2024 - jnnp.bmj.com
The field of biomarker discovery is rapidly expanding. The introduction of ultrasensitive
immunoassays and the growing precision of genetic technologies are poised to …

Investigation and Management of Immunoglobulin M–and Waldenström-Associated Peripheral Neuropathies

O Tomkins, V Leblond, MP Lunn… - Hematology …, 2023 - hemonc.theclinics.com
The immunoglobulin M (IgM)-associated peripheral neuropathies (PNs) are a
heterogeneous group of disorders that can result in significant disability, and together they …

Paraneoplastic Neurologic Syndromes

JJ Graber - CONTINUUM: Lifelong Learning in Neurology, 2023 - journals.lww.com
OBJECTIVE Progress is ongoing in understanding paraneoplastic neurologic disorders, with
new syndromes and antibodies being described and more detailed evidence available to …

Recent insights into haematology and peripheral nerve disease

O Tomkins, MP Lunn - Current Opinion in Neurology, 2024 - journals.lww.com
This review of the current literature focuses on recent updates and developments for the
paraproteinaemic neuropathies, and the evaluation, diagnosis and treatment of peripheral …

Monoclonal gammopathy‐associated peripheral neuropathies: Uncovering pearls and challenges

TAP Gonçalves, CD Donadel… - Journal of the …, 2024 - Wiley Online Library
Monoclonal gammopathy‐related peripheral neuropathies encompass a spectrum of clinical
presentations in which the monoclonal protein directly damages the tissues, including the …

[HTML][HTML] Diagnostic criteria and therapeutic implications of rapid-onset demyelinating polyneuropathies

W Rałowska-Gmoch, M Koszewicz… - Experimental and …, 2024 - Elsevier
Guillain-Barré syndrome (GBS) and acute-onset chronic inflammatory demyelinating
polyneuropathy (A-CIDP) are the most common autoimmune polyneuropathies. Their …

Top 10 Clinical Pearls in Paraproteinemic Neuropathies

B Becker, A Stino - Seminars in Neurology, 2024 - thieme-connect.com
Paraproteinemic neuropathies represent an important subset of peripheral neuropathies.
Once identified, further evaluation into the paraproteinemic subtype, clinical exam pattern …

AL amyloidosis presenting with isolated lumbosacral radiculoplexus neuropathy

R Bellanti, M Symmonds, R Chowdhury, M Hofer… - Practical …, 2023 - pn.bmj.com
A 45-year-old man presented with an isolated sciatic mononeuropathy, which then evolved
into a lumbosacral radiculoplexus neuropathy. His initial symptoms included lower limb …