[HTML][HTML] Targeting Akt in cancer for precision therapy
H Hua, H Zhang, J Chen, J Wang, J Liu… - Journal of Hematology & …, 2021 - Springer
Biomarkers-guided precision therapeutics has revolutionized the clinical development and
administration of molecular-targeted anticancer agents. Tailored precision cancer therapy …
administration of molecular-targeted anticancer agents. Tailored precision cancer therapy …
[HTML][HTML] Evolution of cancer pharmacological treatments at the turn of the third millennium
The medical history of cancer began millennia ago. Historical findings of patients with
cancer date back to ancient Egyptian and Greek civilizations, where this disease was …
cancer date back to ancient Egyptian and Greek civilizations, where this disease was …
[PDF][PDF] Review on epidermal growth factor receptor (EGFR) structure, signaling pathways, interactions, and recent updates of EGFR inhibitors
The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase
receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation …
receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation …
Classification of small molecule protein kinase inhibitors based upon the structures of their drug-enzyme complexes
R Roskoski Jr - Pharmacological research, 2016 - Elsevier
Because dysregulation and mutations of protein kinases play causal roles in human
disease, this family of enzymes has become one of the most important drug targets over the …
disease, this family of enzymes has become one of the most important drug targets over the …
[HTML][HTML] Rethink of EGFR in cancer with its kinase independent function on board
R Thomas, Z Weihua - Frontiers in oncology, 2019 - frontiersin.org
The epidermal growth factor receptor (EGFR) is one of most potent oncogenes that are
commonly altered in cancers. As a receptor tyrosine kinase, EGFR's kinase activity has been …
commonly altered in cancers. As a receptor tyrosine kinase, EGFR's kinase activity has been …
The methylation effect in medicinal chemistry
The monovalent methyl group is derived from methane through the removal of a hydrogen
atom, 1 and its etymology is directly related to the discovery of methanol. 2 The first reports …
atom, 1 and its etymology is directly related to the discovery of methanol. 2 The first reports …
Impact of EGFR inhibitor in non–small cell lung cancer on progression-free and overall survival: a meta-analysis
Background The epidermal growth factor receptor (EGFR) signaling pathway is crucial for
regulating tumorigenesis and cell survival and may be important in the development and …
regulating tumorigenesis and cell survival and may be important in the development and …
ERBB receptors and cancer: the complexity of targeted inhibitors
NE Hynes, HA Lane - Nature Reviews Cancer, 2005 - nature.com
ERBB receptor tyrosine kinases have important roles in human cancer. In particular, the
expression or activation of epidermal growth factor receptor and ERBB2 are altered in many …
expression or activation of epidermal growth factor receptor and ERBB2 are altered in many …
[HTML][HTML] Bax/Bcl-2 cascade is regulated by the EGFR pathway: therapeutic targeting of non-small cell lung cancer
Non-small cell lung carcinoma (NSCLC) comprises 80%–85% of lung cancer cases. EGFR
is involved in several cancer developments, including NSCLC. The EGFR pathway …
is involved in several cancer developments, including NSCLC. The EGFR pathway …
Review of epidermal growth factor receptor biology
RS Herbst - International Journal of Radiation Oncology* Biology …, 2004 - Elsevier
The epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein that
constitutes one of four members of the erbB family of tyrosine kinase receptors. Binding of …
constitutes one of four members of the erbB family of tyrosine kinase receptors. Binding of …