Ubiquitin (Ub) conjugation is a critical signalling process in eukaryotic cells. The precise
regulation of deubiquitination is an important component of this signalling cascade. Here …

Abstract Ubiquitin Specific Protease 7 (USP7) is a deubiquitinating enzyme (DUB) that plays
critical roles in the regulation of many cellular processes including epigenetics, tumour …

USP7, a ubiquitin-specific peptidase (USP), plays an important role in many cellular
processes through its catalytic deubiquitination of various substrates. However, its nuclear …

OTUB1 is a deubiquitinating enzyme that cleaves Lys-48–linked polyubiquitin chains and
also regulates ubiquitin signaling through a unique, noncatalytic mechanism. OTUB1 binds …

Epigenetic regulation involves the coordinated interplay of diverse proteins. To
systematically explore these combinations, we present COMBINE (combinatorial interaction …

In an attempt to unravel functionality of the non-canonical PRC1. 1 Polycomb complex in
human leukemogenesis, we show that USP7 and TRIM27 are integral components of PRC1 …

Background Maintenance of genome integrity during DNA replication is crucial to the
perpetuation of all organisms. In eukaryotes, the bypass of DNA lesions by the replication …

Many clinical studies have shown that embryos of in vitro fertilization (IVF) are often prone to
developmental arrest, which leads to recurrent failure of IVF treatment. Early embryonic …

Abstract Background Long noncoding RNAs (lncRNAs) have been identified as regulators of
a number of developmental and tumorigenic processes. However, the functions of most …

The E3 ubiquitin-protein ligase TRIM21, of the RING-containing tripartite motif (TRIM) protein
family, is a major autoantigen in autoimmune diseases and a modulator of innate immune …