Intranasal insulin for Alzheimer's disease

M Hallschmid - CNS drugs, 2021 - Springer
Brain insulin signaling contributes to memory function and might be a viable target in the
prevention and treatment of memory impairments including Alzheimer's disease. This short …

Frailty as a predictor of cognitive disorders: a systematic review and meta-analysis

MK Borges, M Canevelli, M Cesari… - Frontiers in medicine, 2019 - frontiersin.org
Background/Aim: Current evidence in the literature supports associations between frailty,
cognitive impairment, and dementia. The study aim was to describe the risk of cognitive …

Intranasal insulin

M Hallschmid - Journal of neuroendocrinology, 2021 - Wiley Online Library
The intranasal (IN) route enables the delivery of insulin to the central nervous system in the
relative absence of systemic uptake and related peripheral side effects. Intranasally …

Metabolic syndrome, mild cognitive impairment, and dementia: a meta-analysis of longitudinal studies

AR Atti, S Valente, A Iodice, I Caramella… - The American Journal of …, 2019 - Elsevier
Objective A systematic review and a meta-analysis of both clinical and population-based
studies was undertaken according to the Preferred Reporting Items for Systematic Reviews …

[HTML][HTML] Vascular cognitive impairment–Past, present, and future challenges

A Badji, J Youwakim, A Cooper, E Westman… - Ageing Research …, 2023 - Elsevier
Vascular cognitive impairment (VCI) is a lifelong process encompassing a broad spectrum of
cognitive disorders, ranging from subtle or mild deficits to prodromal and fully developed …

Metabolic syndrome, cognitive impairment and the role of diet: a narrative review

M Kouvari, NM D'cunha, N Travica, D Sergi, M Zec… - Nutrients, 2022 - mdpi.com
Background: This narrative review presents the association between metabolic syndrome
(MetS), along with its components, and cognition-related disorders, as well as the potential …

Inflammation and insulin resistance as risk factors and potential therapeutic targets for Alzheimer's disease

A Vinuesa, C Pomilio, A Gregosa… - Frontiers in …, 2021 - frontiersin.org
Overnutrition and modern diets containing high proportions of saturated fat are among the
major factors contributing to a low-grade state of inflammation, hyperglycemia and …

Metabolic syndrome and cognitive function

M Tahmi, P Palta, JA Luchsinger - Current Cardiology Reports, 2021 - Springer
Abstract Purpose of Review Metabolic syndrome (MetS) is a cluster of cardiovascular
disease risk factors that are related to several adverse health outcomes, including poor …

Identifying and evaluating clinical subtypes of Alzheimer's disease in care electronic health records using unsupervised machine learning

N Alexander, DC Alexander, F Barkhof… - BMC Medical Informatics …, 2021 - Springer
Background Alzheimer's disease (AD) is a highly heterogeneous disease with diverse
trajectories and outcomes observed in clinical populations. Understanding this …

[HTML][HTML] Diabetes mellitus in the young and the old: Effects on cognitive functioning across the life span

E van Duinkerken, CM Ryan - Neurobiology of disease, 2020 - Elsevier
Mild to moderate cognitive decrements are a well-known phenomenon associated with
diabetes mellitus. In this review, we provide an overview of the cognitive consequences of …