Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility,
diminishes quality of life, and can lead to fall-related injuries, which require costly …

Growth hormone (GH) research and its clinical application for the treatment of growth
disorders span more than a century. During the first half of the 20th century, clinical …

Improving physical function and mobility in a continuously expanding elderly population
emerges as a high priority of medicine today. Muscle mass, strength/power, and maximal …

Osteoporosis, a condition of skeletal decline that undermines quality of life, is treated with
pharmacological interventions that are associated with poor adherence and adverse effects …

Objective: The development of these guidelines is sponsored by the American Association
of Clinical Endocrinologists (AACE) Board of Directors and American College of …

In evolutionary terms, GH and intracellular STAT 5 signaling is a very old regulatory system.
Whereas insulin dominates periprandially, GH may be viewed as the primary anabolic …

Background. The declining activity of the growth hormone-insulin-like growth factor I (IGF-I)
axis with advancing age may contribute to the decrease in lean body mass and the increase …

Abstract 333 consecutive patients with hypopituitarism diagnosed between 1956 and 1987
were retrospectively examined. The patients had been given routine replacement therapy …

I. Overview T HE general characterization of the growth hormone/insulin-like growth factor-I
(GH/IGF-I) system has been established for a considerable length of time, and we will not …

Although for most children the process of atherosclerosis is subclinical, dramatically
accelerated atherosclerosis occurs in some pediatric disease states, with clinical coronary …