Abstract Trachea-esophageal defects (TEDs), including esophageal atresia (EA),
tracheoesophageal fistula (TEF), and laryngeal-tracheoesophageal clefts (LTEC), are a …

Background There is growing evidence to demonstrate that the epigenetic regulation of
immune characteristics, especially for N6-methyladenosine (m6A) RNA methylation …

Infants born with esophageal atresia and tracheoesophageal fistula, a complex congenital
malformation occurring in 1/2500–4000 live births, may suffer threats to their cardiac …

Objective Genetic variants in EFTUD2 were proven to influence variable phenotypic
expressivity in mandibulofacial dysostosis Guion-Almeida type (MFDGA) or mandibulofacial …

Esophageal atresias/tracheoesophageal fistulas (EA/TEF) are rare congenital anomalies
caused by aberrant development of the foregut. Previous studies indicate that rare or de …

Introduction Primary cilia play pivotal roles in the patterning and morphogenesis of a wide
variety of organs during mammalian development. Here we examined murine foregut …

ABSTRACT A series of well-regulated cellular and molecular events result in the
compartmentalization of the anterior foregut into the esophagus and trachea. Disruption of …

Understanding the molecular mechanisms of congenital diseases is challenging due to their
occurrence within specific developmental stages. Esophageal malformations are examples …

Background An increase in the demand for a functional cure has accelerated research on
new methods of therapy for chronic hepatitis B, which is mainly focused on restoring antiviral …

Congenital heart disease (CHD) is a collection of anatomically and clinically heterogeneous
structure anomalies of heart at birth. Finding genetic causes of CHD can not only shed light …