Islet transplantation is a well-established therapeutic treatment for a subset of patients with
complicated type I diabetes mellitus. Prior to the Edmonton Protocol, only 9% of the 267 islet …

Islet transplantation may be used to treat type I diabetes. Despite tremendous progress in
islet isolation, culture, and preservation, the clinical use of this modality of treatment is …

Background Registry data on patients with type 1 diabetes mellitus who undergo pancreatic
islet transplantation indicate that only 8 percent are free of the need for insulin therapy at …

Background Islet transplantation offers the potential to improve glycemic control in a
subgroup of patients with type 1 diabetes mellitus who are disabled by refractory …

Islet transplantation can restore endogenous β-cell function to subjects with type 1 diabetes.
Sixty-five patients received an islet transplant in Edmonton as of 1 November 2004. Their …

Islet transplantation offers the prospect of good glycemic control without major surgical risks.
After our initial report of successful islet transplantation, we now provide further data on 12 …

Background Intraportal transplantation of pancreatic islets offers improved glycaemic control
and insulin independence in type 1 diabetes mellitus, but intraportal thrombosis remains a …

Clinical islet transplantation is gaining acceptance as a potential therapy, particularly for
subjects who have labile diabetes or problems with hypoglycemic awareness. The risks of …

ContextIslet allografts from 2 to 4 donors can reverse type 1 diabetes. However, for islet
transplants to become a widespread clinical reality, diabetes reversal must be achieved with …

Transplantation (CIT) Consortium jointly developed and implemented a harmonized process
for manufacture of the allogeneic Purified Human Pancreatic Islet (PHPI) product evaluated …