Bloodstream infections in critically ill patients: an expert statement

JF Timsit, E Ruppé, F Barbier, A Tabah… - Intensive care medicine, 2020 - Springer
Bloodstream infection (BSI) is defined by positive blood cultures in a patient with systemic
signs of infection and may be either secondary to a documented source or primary—that is …

Current status of matrix-assisted laser desorption/ionization–time-of-flight mass spectrometry (MALDI-TOF MS) in clinical diagnostic microbiology

S Tsuchida, H Umemura, T Nakayama - Molecules, 2020 - mdpi.com
Mass spectrometry (MS), a core technology for proteomics and metabolomics, is currently
being developed for clinical applications. The identification of microorganisms in clinical …

Multidrug-resistant bacterial infections in US hospitalized patients, 2012–2017

JA Jernigan, KM Hatfield, H Wolford… - … England Journal of …, 2020 - Mass Medical Soc
Background Multidrug-resistant (MDR) bacteria that are commonly associated with health
care cause a substantial health burden. Updated national estimates for this group of …

Application and perspectives of MALDI–TOF mass spectrometry in clinical microbiology laboratories

E Torres-Sangiao, C Leal Rodriguez, C García-Riestra - Microorganisms, 2021 - mdpi.com
Early diagnosis of severe infections requires of a rapid and reliable diagnosis to initiate
appropriate treatment, while avoiding unnecessary antimicrobial use and reducing …

Evolution of Diagnostic Methods for Helicobacter pylori Infections: From Traditional Tests to High Technology, Advanced Sensitivity and Discrimination Tools

AI Cardos, A Maghiar, DC Zaha, O Pop, L Fritea… - Diagnostics, 2022 - mdpi.com
Rapid diagnosis and treatment application in the early stages of H. pylori infection plays an
important part in inhibiting the transmission of this infection as this bacterium is involved in …

The current level of MALDI-TOF MS applications in the detection of microorganisms: a short review of benefits and limitations

A Haider, M Ringer, Z Kotroczó… - Microbiology …, 2023 - mdpi.com
The available literary data suggest the general applicability and benefits of the Matrix-
assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry (MS) in …

Rapid identification of pathogens, antibiotic resistance genes and plasmids in blood cultures by nanopore sequencing

AM Taxt, E Avershina, SA Frye, U Naseer, R Ahmad - Scientific reports, 2020 - nature.com
Bloodstream infections (BSI) and sepsis are major causes of morbidity and mortality
worldwide. Blood culture-based diagnostics usually requires 1–2 days for identification of …

Recent advances in the race to design a rapid diagnostic test for antimicrobial resistance

H Leonard, R Colodner, S Halachmi, E Segal - ACS sensors, 2018 - ACS Publications
Even with advances in antibiotic therapies, bacterial infections persistently plague society
and have amounted to one of the most prevalent issues in healthcare today. Moreover, the …

MALDI-TOF mass spectrometry technology as a tool for the rapid diagnosis of antimicrobial resistance in bacteria

EJ Yoon, SH Jeong - Antibiotics, 2021 - mdpi.com
Species identification by using matrix-assisted laser desorption/ionization time-of-flight mass
spectrometry (MALDI-TOF MS) is a routine diagnostic process for infectious diseases in …

[HTML][HTML] Rapid phenotypic methods to improve the diagnosis of bacterial bloodstream infections: meeting the challenge to reduce the time to result

G Dubourg, B Lamy, R Ruimy - Clinical Microbiology and Infection, 2018 - Elsevier
Background Administration of appropriate antimicrobial therapy is one of the key factors in
surviving bloodstream infections. Blood culture is currently the reference standard for …