Mechanical stimuli have fundamental roles in articular cartilage during health and disease.
Chondrocytes respond to the physical properties of the cartilage extracellular matrix (ECM) …

Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …

Mechanical stress plays a critical role in cartilage development and homoeostasis.
Chondrocytes are surrounded by a narrow pericellular matrix (PCM), which absorbs …

ABSTRACT The α1β1, α2β1, α10β1 and α11β1 integrins constitute a subset of the integrin
family with affinity for GFOGER-like sequences in collagens. Integrins α1β1 and α2β1 were …

Objective Mechanical factors play a critical role in the physiology and pathology of articular
cartilage, although the mechanisms of mechanical signal transduction are not fully …

Mechanical loading is essential for chondrocyte health. Chondrocytes can sense and
respond to various extracellular mechanical signals through an integrated set of …

Joints that have degenerated as a result of aging or injury contain dead chondrocytes and
damaged cartilage. Some studies have suggested that chondrocyte death precedes …

Osteoarthritis (OA), one of the most common degenerative diseases, is characterized by
progressive degeneration of the articular cartilage and subchondral bone, as well as the …

Sensory corpuscles, or cutaneous end-organ complexes, are complex structures localized at
the periphery of Aβ-axon terminals from primary sensory neurons that primarily work as low …

Early osteoarthritis (OA), characterised by cartilage defects, is a degenerative disease that
greatly affects the adult population. Cell-based tissue engineering methods are being …