Epithelial‐to‐mesenchymal transition (EMT) is implicated in a wide array of malignant
behaviors of cancers, including proliferation, invasion, and metastasis. Most notably, previou …

MicroRNAs (miRNAs) are endogenous, non‐coding RNAs, which have evoked a great deal
of interest due to their importance in many aspects of homeostasis and diseases …

Fibrosis compromises pancreatic ductal carcinoma (PDAC) treatment and contributes to
patient mortality, yet antistromal therapies are controversial. We found that human PDACs …

In recent years, there has been a tremendous and growing interest among researchers to
investigate the role of mircoRNA (miRNA) in normal cellular as well as in disease processes …

EGFR-activating mutations are observed in approximately 15% to 20% of patients with non–
small cell lung cancer. Tyrosine kinase inhibitors have provided an illustrative example of …

Transitory phenotypic changes such as the epithelial–mesenchymal transition (EMT) help
embryonic cells to generate migratory descendants that populate new sites and establish …

Metastasis of tumor cells from primary sites of malignancy to neighboring stromal tissue or
distant localities entails in several instances, but not in every case, the epithelial …

Patients with EGFR-mutant non-small-cell lung cancer (NSCLC) have significantly benefited
from the use of EGFR tyrosine kinase inhibitors (TKIs). However, long-term efficacy of these …

Epithelial mesenchymal transition (EMT) is a physiological process necessary to normal
embryologic development. However in genesis of pathological situations, this transition can …

Epithelial–mesenchymal transition (EMT) has been recognized as a key element of cell
migration and invasion in lung cancer; however, the underlying mechanisms are not fully …