[HTML][HTML] Natural flavonoids exhibit potent anticancer activity by targeting microRNAs in cancer: A signature step hinting towards clinical perfection

HS Tuli, VK Garg, S Bhushan, V Uttam, U Sharma… - Translational …, 2023 - Elsevier
Cancer prevalence and its rate of incidence are constantly rising since the past few
decades. Owing to the toxicity of present-day antineoplastic drugs, it is imperative to explore …

[HTML][HTML] Licorice (Glycyrrhiza glabra L.)-derived phytochemicals target multiple signaling pathways to confer oncopreventive and oncotherapeutic effects

HS Tuli, VK Garg, JK Mehta, G Kaur… - OncoTargets and …, 2022 - ncbi.nlm.nih.gov
Cancer is a highly lethal disease, and its incidence has rapidly increased worldwide over
the past few decades. Although chemotherapeutics and surgery are widely used in clinical …

[HTML][HTML] PD-L1 overexpression induces STAT signaling and promotes the secretion of pro-angiogenic cytokines in non-small cell lung cancer (NSCLC)

A Cavazzoni, G Digiacomo, F Volta, R Alfieri… - Lung Cancer, 2024 - Elsevier
Background Monoclonal antibodies (ICI) targeting the immune checkpoint PD-1/PD-L1
alone or in combination with chemotherapy have demonstrated relevant benefits and …

[HTML][HTML] Apigenin loaded lipoid–PLGA–TPGS nanoparticles for colon cancer therapy: Characterization, sustained release, cytotoxicity, and apoptosis pathways

MA Alfaleh, AM Hashem, TS Abujamel, NA Alhakamy… - Polymers, 2022 - mdpi.com
Colon cancer (CC) is one of major causes of mortality and affects the socio-economic status
world-wide. Therefore, developing a novel and efficient delivery system is needed for CC …

[HTML][HTML] Coding roles of long non-coding RNAs in breast cancer: Emerging molecular diagnostic biomarkers and potential therapeutic targets with special reference to …

D Kashyap, R Sharma, N Goel, HS Buttar… - Frontiers in …, 2023 - frontiersin.org
Dysregulation of epigenetic mechanisms have been depicted in several pathological
consequence such as cancer. Different modes of epigenetic regulation (DNA methylation …

[HTML][HTML] Terpenoid-mediated targeting of STAT3 signaling in cancer: an overview of preclinical studies

F Khan, P Pandey, M Verma, TK Upadhyay - Biomolecules, 2024 - mdpi.com
Cancer has become one of the most multifaceted and widespread illnesses affecting human
health, causing substantial mortality at an alarming rate. After cardiovascular problems, the …

Anticancer potential of oroxylin A: from mechanistic insight to synergistic perspectives

HS Tuli, VK Garg, A Kumar, D Aggarwal… - Naunyn-Schmiedeberg's …, 2023 - Springer
Oroxylin A (OA), a well-known constituent of the root of Scutellariae plants, has been used in
ethnomedicine already for centuries in treating various neoplastic disorders. However, only …

[HTML][HTML] Survival strategies: How tumor hypoxia microenvironment orchestrates angiogenesis

M Yang, Y Mu, X Yu, D Gao, W Zhang, Y Li, J Liu… - Biomedicine & …, 2024 - Elsevier
During tumor development, the tumor itself must continuously generate new blood vessels to
meet their growth needs while also allowing for tumor invasion and metastasis. One of the …

Lung cancer treatment potential and limits associated with the STAT family of transcription factors

P Faida, MKI Attiogbe, U Majeed, J Zhao, L Qu, D Fan - Cellular Signalling, 2023 - Elsevier
Lung cancer is one of the mortal cancers and the leading cause of cancer-related mortality,
with a cancer survival rate of fewer than 5% in developing nations. This low survival rate can …

Recent Insights into the Roles of PEST‐Containing Nuclear Protein

S Guo, R Ding, Q Zhao, X Wang, S Lv, XY Ji - Molecular Biotechnology, 2024 - Springer
PEST-containing nuclear protein (PCNP), a short-lived small nuclear protein with 178 amino
acids, is a nuclear protein containing two PEST sequences. PCNP is highly expressed in …