[HTML][HTML] Reactive astrocytes in central nervous system injury: subgroup and potential therapy
GL Yu, Y Zhang, B Ning - Frontiers in cellular neuroscience, 2021 - frontiersin.org
Traumatic central nervous system (CNS) injury, which includes both traumatic brain injury
(TBI) and spinal cord injury (SCI), is associated with irreversible loss of neurological function …
(TBI) and spinal cord injury (SCI), is associated with irreversible loss of neurological function …
[HTML][HTML] Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling
A pathological hallmark of Alzheimer's disease (AD) is the deposition of amyloid-β (Aβ)
protein in the brain. Physical exercise has been shown to reduce Aβ burden in various AD …
protein in the brain. Physical exercise has been shown to reduce Aβ burden in various AD …
[HTML][HTML] A shear-thinning, ROS-scavenging hydrogel combined with dental pulp stem cells promotes spinal cord repair by inhibiting ferroptosis
Y Ying, Z Huang, Y Tu, Q Wu, Z Li, Y Zhang, H Yu… - Bioactive materials, 2023 - Elsevier
Spinal cord injury (SCI) is a serious clinical disease. Due to the deformability and fragility of
the spinal cord, overly rigid hydrogels cannot be used to treat SCI. Hence, we used TPA and …
the spinal cord, overly rigid hydrogels cannot be used to treat SCI. Hence, we used TPA and …
Microglial dyshomeostasis drives perineuronal net and synaptic loss in a CSF1R+/− mouse model of ALSP, which can be rescued via CSF1R inhibitors
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia is an
autosomal dominant neurodegenerative disease caused by mutations in colony-stimulating …
autosomal dominant neurodegenerative disease caused by mutations in colony-stimulating …
[HTML][HTML] Repurposed anti-cancer epidermal growth factor receptor inhibitors: mechanisms of neuroprotective effects in Alzheimer's disease
HM Mansour, HM Fawzy, AS El-Khatib… - Neural regeneration …, 2022 - journals.lww.com
Numerous molecular mechanisms are being examined in an attempt to discover disease-
modifying drugs to slow down the underlying neurodegeneration in Alzheimer's disease …
modifying drugs to slow down the underlying neurodegeneration in Alzheimer's disease …
Advances in molecular therapies for targeting pathophysiology in spinal cord injury
HN Kim, MR McCrea, S Li - Expert opinion on therapeutic targets, 2023 - Taylor & Francis
Introduction Spinal cord injury (SCI) affects 25,000–50,000 people around the world each
year and there is no cure for SCI patients currently. The primary injury damages spinal cord …
year and there is no cure for SCI patients currently. The primary injury damages spinal cord …
Inhibition of brain epidermal growth factor receptor activation: a novel target in neurodegenerative diseases and brain injuries
Several reports have been published recently demonstrating a beneficial effect of epidermal
growth factor receptor (EGFR) inhibitors in improving pathologic and behavioral conditions …
growth factor receptor (EGFR) inhibitors in improving pathologic and behavioral conditions …
[HTML][HTML] The role and mechanisms of mesenchymal stem cells regulating macrophage plasticity in spinal cord injury
SP Fu, XC Wu, RL Yang, DZ Zhao, J Cheng… - Biomedicine & …, 2023 - Elsevier
Abstract Spinal Cord Injury (SCI) is a devastating neurological disorder comprising primary
mechanical injury and secondary inflammatory response-mediated injury for which an …
mechanical injury and secondary inflammatory response-mediated injury for which an …
[HTML][HTML] Interleukin-1β drives cellular senescence of rat astrocytes induced by oligomerized amyloid β peptide and oxidative stress
D Shang, Y Hong, W Xie, Z Tu, J Xu - Frontiers in Neurology, 2020 - frontiersin.org
Background: Alzheimer's disease (AD) is the leading cause of dementia. With no reliable
treatment that delays or reverses the progress of AD, effective medical drugs, and …
treatment that delays or reverses the progress of AD, effective medical drugs, and …