The transcription factor Sox9 was first discovered in patients with campomelic dysplasia, a
haploinsufficiency disorder with skeletal deformities caused by dysregulation of Sox9 …

SOX4 is an essential developmental transcription factor that regulates stemness,
differentiation, progenitor development, and multiple developmental pathways including …

Mammalian genomes are populated with thousands of transcriptional enhancers that
orchestrate cell-type-specific gene expression programs,,,, but how those enhancers are …

The metabolic functions of androgen receptor (AR) in normal prostate are circumvented in
prostate cancer (PCa) to drive tumor growth, and the AR also can acquire new growth …

Cancer stem cells (CSC) are purported to initiate and maintain tumor growth. Deregulation
of normal stem cell signaling may lead to the generation of CSCs; however, the molecular …

Animal models, particularly mouse models, play a central role in the study of the etiology,
prevention, and treatment of human prostate cancer. While tissue culture models are …

The transcription factor SOX9 is critical for prostate development, and dysregulation of SOX9
is implicated in prostate cancer (PCa). However, the SOX9-dependent genes and pathways …

SOX9 [sex-determining region Y (SRY)-box 9 protein], a high mobility group box
transcription factor, plays critical roles during embryogenesis and its activity is required for …

Abstract The PI3K/Akt pathway is an actively pursued therapeutic target in oncology. In
prostate cancer, the activation of this pathway appears to be characteristic of many …

Recurrent and hormone-refractory prostate cancer (PCA) exhibits aggressive behaviors
while current therapeutic approaches show little effect of prolonging the survival of patients …